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Merck

P4083

Penicillin − Streptomycin − Neomycin Solution Stabilized

liquid, suitable for cell culture, BioReagent

Synonym(s):

Pen-Strep-Neo

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20 ML

$24.00

100 ML

$49.60

$24.00

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About This Item

UNSPSC Code:
12352207
NACRES:
NA.76

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Product Name

Penicillin − Streptomycin − Neomycin Solution Stabilized, formulated to contain ~5,000 units penicillin, 5 mg streptomycin and 10 mg neomycin/mL, 0.1 μm filtered, BioReagent, suitable for cell culture

Quality Level

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

Mode of action

cell wall synthesis | interferes
protein synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

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This Item
G1146G6784P4458
antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes, cell wall synthesis | interferes

mode of action

cell wall synthesis | interferes, protein synthesis | interferes

mode of action

cell wall synthesis | interferes, protein synthesis | interferes

mode of action

cell wall synthesis | interferes, protein synthesis | interferes

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

cell culture | mammalian: suitable

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

product line

BioReagent

product line

BioReagent

product line

BioReagent

product line

BioReagent

form

liquid

form

liquid

form

liquid

form

liquid

Application

Penicillin-Streptomycin-Neomycin Solution Stabilized has been used to immerse alginate scaffold for disinfection.[1][2] It has also been used as a cell culture media supplement to control bacterial contamination.[3]

Biochem/physiol Actions

Mode of Action: This product acts in three ways. Penicillin inhibits bacterial cell wall synthesis. Streptomycin inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding. Neomycin inhibits initiation and elongation during protein synthesis.

Other Notes

20ml,100ml
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
This product is formulated to contain 5,000 units penicillin, 5 mg streptomycin and 10 mg neomycin/mL and is solubilized.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Goro Tanifuji et al.
Scientific reports, 7(1), 11688-11688 (2017-09-17)
Endosymbiotic relationships between eukaryotic and prokaryotic cells are common in nature. Endosymbioses between two eukaryotes are also known; cyanobacterium-derived plastids have spread horizontally when one eukaryote assimilated another. A unique instance of a non-photosynthetic, eukaryotic endosymbiont involves members of the
Cartilage regeneration in SCID mice using a highly organized three-dimensional alginate scaffold
Wang CC, et al.
Biomaterials and Medical Tribology, 33(1), 120-127 (2012)
Seweryn Mroczek et al.
Nature communications, 8(1), 619-619 (2017-09-22)
FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression.
Rich-club organization in effective connectivity among cortical neurons
Nigam S, et al.
The Journal of Neuroscience, 36(3), 670-684 (2016)
A highly organized three-dimensional alginate scaffold for cartilage tissue engineering prepared by microfluidic technology
Wang CC, et al.
Biomaterials, 32(29), 7118-7126 (2011)

Questions

  1. Hello, is this product typically used as is (i.e. undiluted) in cell culture?

    1 answer
    1. P4083 is provided as 100x and suggested working concentration is 1:100 (10 mL per L).

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