O7885

Okadaic acid potassium salt from Prorocentrum concavum

Name: Okadaic acid potassium salt from <I>Prorocentrum concavum</I>
Brand: SIGMA

≥90% (HPLC), powder

Sinónimos:

Slide 1 of 1

Iniciar sesión para ver los precios por organización y contrato.

Seleccione un Tamaño

En este momento no podemos mostrarle ni los precios ni la disponibilidad

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₄₄H₆₇KO₁₃

Número CAS:

155751-72-7

Peso molecular:

843.09

NACRES:

NA.77

PubChem Substance ID:

24898050

UNSPSC Code:

12352106

MDL number:

MFCD00214356

Documentos clave

Ver Toda la documentación

Saltar a

Servicio técnico

¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.

Permítanos ayudarle

Nombre del producto

Okadaic acid potassium salt from Prorocentrum concavum, ≥90% (HPLC), powder

InChI

1S/C46H72O13.K/c1-27-20-35(56-46(22-27)36(48)12-15-42(7,59-46)24-43(8,52)40(50)51)28(2)10-14-41(6)17-18-45(58-41)16-11-34-39(57-45)37(49)30(4)38(55-34)33(47)21-29(3)32-23-44(26-54-31(32)5)13-9-19-53-25-44;/h10,14,22,28-29,31-39,47-49,52H,4,9,11-13,15-21,23-26H2,1-3,5-8H3,(H,50,51);/q;+1/p-1/b14-10+;

SMILES string

[K+].CC(CC(O)C1OC2CCC3(CCC(C)(O3)\C=C\C(C)C4CC(C)=CC5(O4)OC(C)(CCC5O)CC(C)(O)C([O-])=O)OC2C(O)C1=C)C6CC7(CCCOC7)COC6C

InChI key

CWKZDWKRECTBCU-KMZJGFRYSA-M

biological source

plant (Prorocentrum concavum)

assay

≥90% (HPLC)

form

powder

color

white

solubility

H₂O: 0.1 mg/mL
DMSO: soluble
ethanol: soluble

storage temp.

−20°C

Quality Level

200

Categorías relacionadas

Bioactive Small Molecule Inhibitors

Comparar elementos similares

Ver comparación completa

Mostrar Diferencias

1 of 4

Este artículo	O8010	O7760	O9381
Sigma-Aldrich O7885 Okadaic acid potassium salt from Prorocentrum concavum	Sigma-Aldrich O8010 Okadaic acid ammonium salt from Prorocentrum concavum	Sigma-Aldrich O7760 Okadaic acid sodium salt from Prorocentrum concavum	Sigma-Aldrich O9381 Okadaic acid from Prorocentrum concavum
form powder	form solid	form film	form powder
assay ≥90% (HPLC)	assay ≥90% (HPLC)	assay ≥90% (HPLC)	assay 92-100% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: 0.1 mg/mL, ethanol: soluble, DMSO: soluble	solubility H₂O: 0.1 mg/mL, DMSO: soluble, ethanol: soluble	solubility 0.1% acetic acid in CH₃CN: H₂O (1:1): 250 μg/mL, clear, colorless	solubility DMSO: ≥1 mg/mL, ethanol: ≥1 mg/mL, methanol: ≥1 mg/mL, H₂O: insoluble
color white	color white	color translucent	color -

Biochem/physiol Actions

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

Okadaic acid is a dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid.

pictograms

GHS06

signalword

Danger

hcodes

H301 + H311 + H331,H315

pcodes

P261 - P280 - P301 + P330 + P331 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P403 + P233

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Metformin rescues Parkin protein expression and mitophagy in high glucose-challenged human renal epithelial cells by inhibiting NF-κB via PP2A activation.

Yulan Zhao et al.

Life sciences, 246, 117382-117382 (2020-02-01)

Our preliminary research revealed that metformin, a classic anti-diabetic drug, could rescue Parkin protein expression and mitophagy in high glucose-challenged human renal epithelial cells in vitro, but the molecular mechanism remains to be explored. In the study, Human Renal Cortical

Microelectromechanical System Measurement of Platelet Contraction: Direct Interrogation of Myosin Light Chain Phosphorylation.

Mitchell J George et al.

International journal of molecular sciences, 22(12) (2021-07-03)

Myosin Light Chain (MLC) regulates platelet contraction through its phosphorylation by Myosin Light Chain Kinase (MLCK) or dephosphorylation by Myosin Light Chain Phosphatase (MLCP). The correlation between platelet contraction force and levels of MLC phosphorylation is unknown. We investigate the

Tumor Suppressing Subtransferable Candidate 4 Expression Prevents Autophagy-Induced Cell Death Following Temozolomide Treatment in Glioblastoma Cells.

Yongqiang Chen et al.

Frontiers in cell and developmental biology, 10, 823251-823251 (2022-03-22)

Glioblastoma (GBM) is the most common and aggressive type of brain cancer in adults, with temozolomide (TMZ) being widely used as the standard chemotherapy drug for its treatment. However, GBM frequently becomes resistant to TMZ treatment due to various mechanisms

Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness.

Huijing Yin et al.

Nature communications, 12(1), 4230-4230 (2021-07-11)

Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report in this study that the secretory ECM1a isoform induces tumorigenesis through the GPR motif binding to

Autophagy inhibition by TSSC4 (tumor suppressing subtransferable candidate 4) contributes to sustainable cancer cell growth.

Yongqiang Chen et al.

Autophagy, 18(6), 1274-1296 (2021-09-18)

Cancer cell growth is dependent upon the sustainability of proliferative signaling and resisting cell death. Macroautophagy/autophagy promotes cancer cell growth by providing nutrients to cells and preventing cell death. This is in contrast to autophagy promoting cell death under some

Ver todos los artículos relacionados

Questions

Reviews

No rating value

Active Filters

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico

Okadaic acid potassium salt from Prorocentrum concavum

≥90% (HPLC), powder

Seleccione un Tamaño

Acerca de este artículo

Documentos clave

Saltar a

Propiedades

Nombre del producto

InChI

SMILES string

InChI key

biological source

assay

form

color

solubility

storage temp.

Quality Level

Categorías relacionadas

Comparar elementos similares

Este artículo

Descripción

Biochem/physiol Actions

Información de seguridad

pictograms

signalword

hcodes

pcodes

Hazard Classifications

Clase de almacenamiento

wgk

flash_point_f

flash_point_c

ppe

Documentación

Certificados de análisis (COA)

¿Ya tiene este producto?

Artículos con revisión científica externa.

Questions

Reviews

Active Filters

Servicio técnico