Active thionium species mediated functionalization at the 2α-position of indole derivatives.

Active thionium species mediated functionalization at the 2α-position of indole derivatives.

Chemical communications (Cambridge, England) (2011-05-11)

Kazuhiro Higuchi, Masanori Tayu, Tomomi Kawasaki

RESUMEN

A combination of dimethyl sulfoxide (DMSO) and trifluoroacetic anhydride (TFAA) mediates functionalization at the 2α-position of indole derivatives. Carbon and heteroatom nucleophiles were directly introduced via a one-pot procedure in excellent yields.

MATERIALES

Número de producto

Marca

Descripción del producto

106232

Sigma-Aldrich

Trifluoroacetic anhydride, ReagentPlus^®, ≥99%

91719

Supelco

Trifluoroacetic anhydride, derivatization grade (GC derivatization), LiChropur^™, ≥99.0% (GC)