A convenient synthesis of glycosyl chlorides from sugar hemiacetals using triphosgene as the chlorine source.

A convenient synthesis of glycosyl chlorides from sugar hemiacetals using triphosgene as the chlorine source.

Carbohydrate research (2000-11-10)

R M Cicchillo, P Norris

RESUMEN

Treating partially protected sugar hemiacetals with triphosgene in THF results in the formation of glycosyl chlorides. The method is compatible with acid-sensitive isopropylidene protecting groups in the hemiacetal substrates.

MATERIALES

Número de producto

Marca

Descripción del producto

330752

Sigma-Aldrich

Triphosgene, reagent grade, 98%

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15217

Sigma-Aldrich

Bis(trichloromethyl) carbonate, purum, ≥99.0% (AT)

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