GRIA2
glutamate receptor, ionotropic, AMPA 2
Synonyme:
GLUR2, GLURB, GluA2, GluR-K2, HBGR2
Spezies:
Human GRIA2 (2891), Mouse Gria2 (14800), Rat Gria2 (29627), chicken GRIA2 (414894), cow GRIA2 (614283), naked mole-rat Gria2 (101708417), domestic guinea pig Gria2 (100379153), sheep GRIA2 (443272), Horse GRIA2 (100069331), domestic cat GRIA2 (101088234)
UniProtKB-ID:
Gen-ID:
- Human(2891) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
- Mouse(14800) glutamate receptor, ionotropic, AMPA2 (alpha 2)
- Rat(29627) glutamate receptor, ionotropic, AMPA 2
- chicken(414894) glutamate receptor, ionotropic, AMPA 2
- cow(614283) glutamate receptor, ionotropic, AMPA 2
- naked mole-rat(101708417) glutamate receptor, ionotropic, AMPA 2
- domestic guinea pig(100379153) glutamate receptor, ionotropic, AMPA2 (alpha 2)
- sheep(443272) glutamate receptor, ionotropic, AMPA 2
- Horse(100069331) glutamate receptor, ionotropic, AMPA 2
- domestic cat(101088234) glutamate receptor, ionotropic, AMPA 2
- dog(482667) glutamate receptor, ionotropic, AMPA 2
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Small Molecule - Agonist
Produktnummer
Beschreibung
Spezies
2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide, ≥98% (HPLC), solid,
Spezies
human
Small Molecule - Allosteric Modulator
Produktnummer
Beschreibung
Spezies
Small Molecule - Antagonist
Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Glutamatrezeptor 2/3-Antikörper, Chemicon®, from rabbit,
Speziesreaktivität
gerbil, guinea pig, hamster, human, monkey, mouse, rat
Anwendung
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-GluR2-Antikörper, from rabbit, purified by affinity chromatography,
Speziesreaktivität
human, mouse, rat
Anwendung
immunohistochemistry
western blot
western blot
Anti-GluR2/3-Antikörper, Upstate®, from rabbit,
Speziesreaktivität
chicken, human, monkey, mouse, rat
Anwendung
immunoprecipitation (IP)
western blot
western blot
Anti-GluR2 Antibody, clone 6C4, Alexa Fluor™ 488 Conjugate, clone 6C4, from mouse, ALEXA FLUOR™ 488,
Speziesreaktivität
mouse, rat
Anwendung
immunocytochemistry
immunohistochemistry
immunohistochemistry
Anti-phospho-GluR2 (pSer880) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Blocker
Produktnummer
Beschreibung
Spezies
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Spezies
human
Small Molecule - Mixed Agonist/Antagonist
Produktnummer
Beschreibung
Spezies
L-Glutaminsäure, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Spezies
rat, human