A6816

(±)-AMPA

solid

• Synonym(e): (±)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate
• Empirische Formel (Hill-System): C₇H₁₀N₂O₄
• Molekulargewicht: 186.17
• NACRES: NA.32
• PubChem Substance ID: 24891141
• UNSPSC Code: 12352100
• MDL number: MFCD00213388
• Form: solid

Eigenschaften

• form: solid
• Quality Segment: 200
• color: white
• solubility: H₂O: 1 mg/mL (warm), 0.1 M HCl: 3.5 mg/mL, 0.1 M NaOH: 4.3 mg/mL, DMSO: 4.3 mg/mL, 1 M HCl: 50 mg/mL
• SMILES string: O.Cc1onc(O)c1CC(N)C(O)=O
• InChI: 1S/C7H10N2O4.H2O/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H2
• InChI key: HFISYNCCKQHIAM-UHFFFAOYSA-N
• Gene Information: rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grin2a(24409), Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418), Slc1a1(25550), Slc1a2(29482), Slc1a3(29483) ;

Beschreibung

Application

(±)-AMPA has been used:

• in vivo

• whole-cell patch-clamp recording in Müller glial cells
• to test its excitotoxic effects in hippocampal slice cultures
• in retinal horizontal cells (HCs) culture to test its effect on Ca²⁺ signals

Biochem/physiol Actions

Potent excitatory amino acid that interacts selectively with central AMPA/kainate receptors.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)