A9603

Anti-Aph-1aL antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• UNSPSC Code: 12352203
• MDL number: MFCD06411839

Eigenschaften

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 30 kDa
• species reactivity: human
• technique(s): western blot: 2-4 μg/mL using whole extract of human kidney 293 cells transfected with human Aph-1aL
• UniProt accession no.: Q96BI3
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... APH1A(51107)

Beschreibung

General description

Aph-1aL is a γ secretase subunit that facilitates the cleavage of several integral membrane proteins such as β-APP and Notch. Aph-1aL abnormalities have been associated with the risk of Alzheimer′s disease.
Rabbit Anti-Aph-1aL antibody recognizes Aph-1aL (30 kDa). Additional bands at approx. 46kDa and 20kDa may be observed in some cell extracts, which may represent Aph-1aL aggregation and degradation products, respectively.

This sequence is identical in mouse Aph-1aL and not found in Aph-1aS and Aph-1b.

Immunogen

synthetic peptide corresponding to amino acids 246-265 located at the C-terminus of human Aph-1aL.

Application

Rabbit Anti-Aph-1aL antibody has been used for western blot applications.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable