C1244

CHM-1 hydrate

≥99% (HPLC), solid

• Synonym(e): 2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158
• Empirische Formel (Hill-System): C₁₆H₁₀FNO₃ · xH₂O
• CAS-Nummer: 154554-41-3
• Molekulargewicht: 283.25 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329774746
• UNSPSC Code: 12352202
• MDL number: MFCD11114577
• Assay: ≥99% (HPLC)
• Form: solid
• Storage condition: desiccated

Eigenschaften

• assay: ≥99% (HPLC)
• form: solid
• storage condition: desiccated
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: O.Fc1ccccc1C2=CC(=O)c3cc4OCOc4cc3N2
• InChI: 1S/C16H10FNO3.H2O/c17-11-4-2-1-3-9(11)12-6-14(19)10-5-15-16(21-8-20-15)7-13(10)18-12;/h1-7H,8H2,(H,18,19);1H2
• InChI key: KIAVGSCBJYDTIM-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

CHM-1 possess antimitotic and antiangiogenic antitumor activity.

CHM-1 possess antimitotic,antiangiogenic and antitumor activity. It is a potent and selective antitumor agent in human hepatocellular carcinoma. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)