L5170

Leukotriene A₄ Hydrolase human

recombinant, expressed in E. coli

• Synonym(e): LTA-4 hydrolase, LTA4, LTA₄H
• CAS-Nummer: 90119-07-6
• UNSPSC Code: 12352204
• NACRES: NA.54
• EG-Nummer: 3.3.2.6 (BRENDA, IUBMB)
• MDL number: MFCD08460576

Eigenschaften

• recombinant: expressed in E. coli
• description: contains C-terminal his-tag
• assay: ≥90% (SDS-PAGE)
• mol wt: ~69 kDa
• NCBI accession no.: NP_000886
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... LTA4H(4048)

Beschreibung

Application

Leukotriene A4 Hydrolase human (LTA4H) is a drug target for anti-inflammation, and for cancer prevention and therapy. It is also suitable for screening inhibitors of Leukotriene B4 synthesis. LTA4H is used to study allergic asthma and airway hyperresponsiveness .

Biochem/physiol Actions

Leukotriene A4 Hydrolase human (LTA4H) is a bifunctional zinc metalloenzyme that converts LTA4 into Leukotriene B4, and also demonstrates aminopeptidase activity. Leukotriene B4 is a lipid chemoattractant that plays critical roles in inflammaton, immune responses, host defenses against infections, and lipid homeostasis. Inhibition of LTA4H in a mouse model decreases LTB4 in the airways and attenuates airway inflammation and airway hyperreactivity through modulation of T cell and dendritic cell function .

Physical form

Supplied as a solution in 100mM Tris, pH 8.0, containing 20% glycerol and 100mM potassium chloride.

Sicherheitshinweise

• Lagerklasse: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable