M8523

Anti-β₂-Microglobulin antibody produced in rabbit

whole antiserum

• Synonym(e): Anti-B2MG
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00162400
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ELISA (i)
• Citations: 13

Eigenschaften

• biological source: rabbit
• conjugate: unconjugated
• antibody form: whole antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• contains: 15 mM sodium azide
• species reactivity: human
• packaging: antibody small pack of 25 μL
• technique(s): indirect ELISA: 1:5,000
• UniProt accession no.: P61769
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... B2M(567)

Beschreibung

General description

β-2-microglobulin is part of the human leukocyte antigen, where it represents the light chain. It is expressed on cell membranes and is made up of 99 amino acids. β-2-microglobulin is part of the immunoglobulin superfamily.

β2-microglobulin (B2M) is a non-glycosylated polypeptide. The protein is characterized with a single polypeptide chain, which is linked noncovalently to major histocompatibility complex (MHC) class I cell surface antigen. The gene coding for B2M is mapped to human chromosome 15q.

Immunogen

β₂-microglobulin

Application

Anti-β2-Microglobulin antibody produced in rabbit has been used in immunoblottingand immunofluorescence.

Biochem/physiol Actions

β-2-microglobulin acts as a tumor marker and has been shown to be associated with dialysis-related amyloidosis.

β2-microglobulin (B2M) plays a vital role in cell survival, proliferation and metastasis in various types of cancer. Elevated concentration of β-2-microglobulin (B2M) can be considered as a prognostic marker for hemophagocytic lymphohistiocytosis (HLH). Overexpression of serum B2M is observed in hepatitis C virus (HCV) related chronic liver diseases, therefore it might act as a potential marker for the HCV disease progression towards cirrhosis and carcinoma. Missense mutation in the B2M gene results in familial hypercatabolic hypoproteinemia (FHH).

Analysis Note

The antiserum has been treated to remove lipoprotens.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Was ist los?: WGK 3