O9765

Orientin

≥97% (HPLC)

• Synonym(e): 8-β-D-Glucopyranosyl-3′,4′,5,7-tetrahydroxyflavon, Luteolin-8-C-β-D-glucopyranosid, Luteolin-8-glucosid, Lutexin
• Empirische Formel (Hill-System): C₂₁H₂₀O₁₁
• CAS-Nummer: 28608-75-5
• Molekulargewicht: 448.38
• NACRES: NA.25
• PubChem Substance ID: 329818945
• UNSPSC Code: 12352205
• MDL number: MFCD00017432

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: yellow
• solubility: 1 M NaOH: 1 mg/mL, clear, yellow-orange
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• SMILES string: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccc(O)c(O)c4
• InChI: 1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2/t14-,17-,18+,19-,21+/m1/s1
• InChI key: PLAPMLGJVGLZOV-VPRICQMDSA-N

Beschreibung

General description

Orientin (ORI) is a luteolin derivative and water soluble 8-C-glucoside dietary flavone. It has one ketone, two ether, and phenyl groups in its chemical structure. Orientin is sourced from many medicinal plants such as Ocimum sanctum (holy basil), Phyllostachys species (bamboo leaves), Passiflora species, Trollius species, etc.

Application

Orientin has been used:

• as an anti-inflammatory and anti-proliferative agent to test its protective effects against 1,2-dimethyl hydrazine (DMH)-induced colorectal cancer in rats model
• as a flavanoid to investigate its protective effects against mitochondrial dysfunction on antimycin-A induced murine C2C12 skeletal muscle cells
• as a potential endonuclease inhibitor of influenza polymerase PA subunit

Biochem/physiol Actions

Flavonoidglycoside aus Kohlpalmen, Trollblumen und Passionsblumen. Antiviraler Wirkstoff, antimikrobielle und antioxidative Wirkung. Radioprotektiv.

Orientin displays neuroprotective effects against hydrogen peroxide-induced SH-SY5Y neuroblastoma cells. It exerts antioxidant, anti-inflammation, antiaging, antidepressant-like, vasodilation, vasorelaxant, and cardioprotective effects.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable