P2795

Phytosphingosine hydrochloride

• Synonym(e): 4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS
• Empirische Formel (Hill-System): C₁₈H₃₉NO₃ · HCl
• CAS-Nummer: 554-62-1
• Molekulargewicht: 353.97
• NACRES: NA.25
• PubChem Substance ID: 24898363
• UNSPSC Code: 12352211
• MDL number: MFCD06804643
• eCl@ss: 32035490

Eigenschaften

• form: powder
• Quality Segment: 200
• greener alternative product score: old score: 19; new score: 9; Find out more about DOZN™ Scoring
• sustainability: Sustainability features
• lipid type: sphingolipids
• storage temp.: −20°C
• SMILES string: Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
• InChI: 1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1
• InChI key: GDKAAHDFPOWGQE-RXQQAGQTSA-N

Beschreibung

Biochem/physiol Actions

Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨ_m and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)