SML1863

NSC57969

≥98% (HPLC)

• Synonym(e): 7-(1-Piperidinylmethyl)-8-quinolinol, 7-(Piperidinomethyl)-8-quinolinol, 8-Hydroxy-7-(piperidinomethyl)quinoline
• Empirische Formel (Hill-System): C₁₅H₁₈N₂O
• CAS-Nummer: 6632-09-3
• Molekulargewicht: 242.32
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00469245
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: OC1=C(N=CC=C2)C2=CC=C1CN3CCCCC3
• InChI: 1S/C15H18N2O/c18-15-13(11-17-9-2-1-3-10-17)7-6-12-5-4-8-16-14(12)15/h4-8,18H,1-3,9-11H2
• InChI key: WXMFPLZGDXLEMN-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines

NSC57969 is a MDR-selective compound that exhibits a robust Pgp-dependent toxic activity across diverse cancer cell lines. NSC57969 shows profound toxicity against doxorubicin resistant Brca1-/-;p53-/- spontaneous mouse mammary carcinoma cells. NSC57969 eradicates P-glycoprotein expression in doxorubicin resistant brca1-/-;p53-/- spontaneous mouse mammary carcinoma, and MES-SA/Dx5 cells. However treatment of normal cells (hCMEC/D3 cells) with NSC57969 does not induce loss of Pgp.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable