SML2390

JNS 1-40

≥95% (HPLC)

• Synonym(e): N-benzyl-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide
• Empirische Formel (Hill-System): C₁₇H₁₆ClNO₃
• CAS-Nummer: 2241773-03-3
• Molekulargewicht: 317.77
• UNSPSC Code: 12352200
• NACRES: NA.21
• Assay: ≥95% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(CCl)N(CC1=CC=CC=C1)C2=CC3=C(OCCO3)C=C2
• InChI: 1S/C17H16ClNO3/c18-11-17(20)19(12-13-4-2-1-3-5-13)14-6-7-15-16(10-14)22-9-8-21-15/h1-7,10H,8-9,11-12H2
• InChI key: POYZNHCCXQEULA-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

JNS 1-40 is a potent and selective cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the tumor-suppressor protein phosphatase 2A (PP2A) that activate PP2A in vitro and in vivo. JNS 1-40 targets C377 of PPP2R1A and inhibits breast cancer proliferation, and in vivo tumor growth.

cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the PP2A that activate PP2A

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable