SML2884

ML184

≥98% (HPLC)

• Synonym(e): 3-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]-N,N-dimethyl-4-pyrrolidin-1-ylbenzenesulfonamide, 3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide, CID 2440433, CID-2440433, CID2440433, ML 184, ML-184
• Empirische Formel (Hill-System): C₂₅H₃₄N₄O₃S
• CAS-Nummer: 794572-10-4
• Molekulargewicht: 470.63
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD06367291
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CN(S(=O)(C1=CC(C(N2CCN(C3=C(C(C)=CC=C3)C)CC2)=O)=C(N4CCCC4)C=C1)=O)C
• InChI: 1S/C25H34N4O3S/c1-19-8-7-9-23(20(19)2)28-14-16-29(17-15-28)25(30)22-18-21(33(31,32)26(3)4)10-11-24(22)27-12-5-6-13-27/h7-11,18H,5-6,12-17H2,1-4H3
• InChI key: VRSJAHQGJHDACS-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

ML184 (CID2440433) is a selective G-protein coupled receptor GPR55 (LPIR1) agonist (EC₅₀ = 0.26 μM vs. >32 μM toward GPR35 & CB1/2 by cell-based βarr2 recruitment assay; antagonist IC₅₀ = 15.1, 21.8, >32 μM, respectively, against CB2, CB1, GPR35). ML184 is 18-times more potent than lysophosphatidylinositol in stimulating cellular ERK1/2 phosphorylation (GPR55E- & βarr2-GFP-expressing U2OS cells) and is at least 10-times more potent than CID1792197 or CID1172084 (ML185) in inducing PKCβII translocation (GPR55E- & PKCβII-GFP-expressing HEK293 cells).

Potent and selective G-protein coupled receptor GPR55 (LPIR1) agonist.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3