SML3347

NPSP795 hydrochloride

≥95% (HPLC)

• Synonym(e): (R)-3-(4-Cyano-3-(3-((1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl)amino)-2-hydroxypropoxy)phenyl)propanoic acid hydrochloride, 4-Cyano-3-[(2R)-3-[[2-(2,3-dihydro-1H-inden-2-yl)-1,1-dimethylethyl]amino]-2-hydroxypropoxy]benzenepropanoic acid hydrochloride, SB-423562 hydrochloride, SHP635
• Empirische Formel (Hill-System): C₂₆H₃₂N₂O₄ · xHCl
• Molekulargewicht: 436.54 (free base basis)
• UNSPSC Code: 41121801
• NACRES: NA.77
• MDL number: MFCD19443794
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: O=C(O)CCC1=CC=C(C#N)C(OC[C@H](O)CNC(C)(C)CC2CC3=C(C=CC=C3)C2)=C1
• InChI: 1S/C26H32N2O4/c1-26(2,14-19-11-20-5-3-4-6-21(20)12-19)28-16-23(29)17-32-24-13-18(8-10-25(30)31)7-9-22(24)15-27/h3-7,9,13,19,23,28-29H,8,10-12,14,16-17H2,1-2H3,(H,30,31)/t23-/m1/s1
• InChI key: NJBFJCJKWWIKRD-HSZRJFAPSA-N

Beschreibung

Biochem/physiol Actions

Calcium-sensing receptor negative allosteric modulator; suppress airway hyperresponsiveness and inflammation in human cells and murine asthma surrogates

NPSP795 is a calcium-sensing receptor negative allosteric modulator (CaSR NAMs). NPSP795 suppress airway hyperresponsiveness and inflammation in human cells and murine asthma surrogates. It does not alter blood pressure, heart rate or serum calcium concentrations.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable