SML3732

BAY-4931

≥98% (HPLC)

• Synonym(e): 2-Chloro-N-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]-5-nitrobenzamide, BAY 4931, BAY4931
• Empirische Formel (Hill-System): C₂₂H₁₆ClN₃O₄
• CAS-Nummer: 423150-91-8
• Molekulargewicht: 421.83
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC([N+]([O-])=O)=CC=C1Cl)NC2=CC=C3OC(C4=CC=C(C=C4)CC)=NC3=C2
• InChI: 1S/C22H16ClN3O4/c1-2-13-3-5-14(6-4-13)22-25-19-11-15(7-10-20(19)30-22)24-21(27)17-12-16(26(28)29)8-9-18(17)23/h3-12H,2H2,1H3,(H,24,27)
• InChI key: WFEBALYYDASKIV-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

BAY-4931 is a potent and selective covalent PPARγ inverse agonist (IC50 = 0.17 nM, max inhibition = 94% by cell-based reporter assays) that induces interactions between the PPARγ ligand-binding domain (LBD) and the corepressor NCOR2 (EC50 = 5.8 nM, Emax = 619% by TR-FRET). BAY-4931 exhibits anti-proliferation efficacy against PPARγ-dependent growth in cultures (UM-UC9 IC50 = 3.4 nM, max inhibition = 79%).

Potent and selective covalent PPARγ inverse agonist with anti-proliferation efficacy against PPARγ-dependent growth in cultures.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable