SML4076

VU0542270

≥98% (HPLC)

• Synonym(e): N-[[4-Methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N′-2-thienylurea
• Empirische Formel (Hill-System): C₁₄H₁₃N₃OS₃
• CAS-Nummer: 1396814-79-1
• Molekulargewicht: 335.47
• MDL number: MFCD22622541
• NACRES: NA.21
• UNSPSC Code: 12352200
• eCl@ss: 32160703
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC1=C(CNC(NC2=CC=CS2)=O)SC(C3=CC=CS3)=N1

Beschreibung

Biochem/physiol Actions

Potent and highly selective inhibitor of vascular Kir6.1/SUR2B (vascular KATP) channels.


VU0542270 is a potent and highly selective inhibitor of vascular Kir6.1/SUR2B (vascular KATP) channels (IC50 ~ 100 nM) that show no apparent activity toward Kir6.2/SUR1 and other members of the Kir channel family. It appears that VU0542270 binds to SUR2. It has a rather short in vivo half-life (t1/2 = 0.64 hour).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable