SML4299

TAK-448 acetate salt

≥95% (HPLC), (Powder or Lyophilized powder or film), kisspeptin agonist

• Synonym(e): Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 acetate, N-Acetyl-D-tyrosyl-(4R)-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl-2-azaglycyl-L-leucyl-N5-[imino(methylamino)methyl]-L-ornithyl-L-tryptophanamide acetate
• Empirische Formel (Hill-System): C₅₈H₈₀N₁₆O₁₄ · xC₂H₄O₂
• Molekulargewicht: 1225.35 (free base basis)
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: (Powder or Lyophilized powder or film)
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: (Powder or Lyophilized powder or film)
• storage condition: desiccated
• color: white to off-white
• storage temp.: -10 to -25°C

Beschreibung

General description

RVT-602 (TAK-448) is a Kisspeptin analog. It is a nonapeptide, ending with Arg-Trp-NH2 sequence.

Application

TAK-448 may be used to investigate its pharmacodynamic properties through receptor binding and agonistic assays, and to assess its impact on plasma drug and testosterone levels in rat models.

Biochem/physiol Actions

TAK-448 acts by stimulatiing stimulating GnRH secretion, increasing the release of LH and FSH. Sustained exposure results in a transient increase in plasma testosterone followed by potent suppression of testosterone levels.

Disclaimer

Hygroscopic Store with desiccant

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable