SML4491

MitoQ

≥98% (HPLC)

• Synonym(e): (10-(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl) triphenylphosphonium mesylate), MitoQ mesylate, Mitoquinone mesylate, Mitoquinone methanesulfonate, [10-(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl]triphenyl-phosphonium methanesulfonate
• Empirische Formel (Hill-System): C₃₇H₄₄O₄P·CH₃O₃S
• CAS-Nummer: 845959-50-4
• Molekulargewicht: 678.81
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: oil
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: oil
• storage condition: desiccated
• color: faint orange to red
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Mitoquinone mesylate (MitoQ), a TPP-CoQ10 conjugate, selectively accumulates 1,000-fold in the mitochondrial matrix via membrane potential (ΔΨm), redox cycling ubiquinol to ubiquinone, reducing ROS, upregulating endogenous antioxidants. Targeted delivery confers ~800-fold greater efficacy than untargeted antioxidants in preventing cell death, exhibiting antiproliferative effects in cancer (IC50s: 0.38 µM proliferation, 0.52 µM complex I inhibition). MitoQ provides systemic benefits (improved vascular/metabolic function, reduced liver inflammation/fibrosis), demonstrating chondrocyte cytotoxicity (1.094 mM) and efficacy in canine mammary gland tumor cells, offering a superior strategy combating organelle-specific oxidative stress and dysfunction across pathologies.

Disclaimer

Hygroscopic, Store with desiccant

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable