SML4492

Clonixeril

≥98% (HPLC)

• Synonym(e): 2,3-Dihydroxypropyl 2-((3-chloro-2-methylphenyl)amino)nicotinate, 2,3-Dihydroxypropyl 2-(3-chloro-o-toluidino)nicotinate, NSC 335504, Sch 12707
• Empirische Formel (Hill-System): C₁₆H₁₇ClN₂O₄
• CAS-Nummer: 21829-22-1
• Molekulargewicht: 336.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Clonixeril (CXL) is a cell-permeable non-nucleotide that uniquely modulates hSTING, acting as either a weak partial agonist or a highly potent antagonist. Its antagonistic mechanism—blocking STING oligomerization and phosphorylation (Ser366)—is critically dependent on pre-agonist administration, as it cannot reverse pre-formed, disulfide-stabilized oligomers. Consequently, Clonixeril employs a non-classical, non-stoichiometric mechanism distinct from simple competitive antagonism.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable