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V3501

Vitamin K1

viscous liquid

Synonym(e):

2-Methyl-3-phytyl-1,4-naphthochinon, 3-Phytylmenadion, Phyllochinon, Vitamin K1(20)

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Größe/SKUVerfügbarkeitPreis
1 g
Warenkorb auf Verfügbarkeit prüfen
€ 183,00
5 g
Warenkorb auf Verfügbarkeit prüfen
€ 545,00
10 g
Warenkorb auf Verfügbarkeit prüfen
€ 955,00

Über diesen Artikel

Empirische Formel (Hill-System):
C31H46O2
CAS-Nummer:
Molekulargewicht:
450.70
NACRES:
NA.28
PubChem Substance ID:
eCl@ss:
34058015
UNSPSC Code:
12352205
EC Number:
201-564-2
MDL number:
Beilstein/REAXYS Number:
2568816

€ 183,00


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biological source

synthetic (organic
inorganic)

Quality Segment

form

viscous liquid

color

, Yellow to Very Dark Yellow to Very Dark Orange

refractive index

n20/D 1.527 (lit.)

mp

−20 °C (lit.)

density

0.984 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C21)C(C)=C(C/C=C(CCC[C@@H](CCC[C@H](C)CCCC(C)C)C)\C)C2=O

InChI

1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

InChI key

MBWXNTAXLNYFJB-NKFFZRIASA-N

General description

Vitamin K1/Phyllochinon ist ein prenyliertes Naphthochinon. Es wird von Pflanzen, Grünalgen und einigen Spezies von Blaualgen erzeugt.

Application

Vitamin K1 wird bei der Herstellung von Kulturmedium eingesetzt.

Biochem/physiol Actions

Vitamin K1 (Phyllochinon) ist ein lipidlösliches, polyzyklisches, aromatisches Keton, das als Co-Faktor bei der Bildung der Gerinnungsfaktoren II (Prothrombin), VII, IX und X, der gerinnungshemmenden Faktoren C und S sowie als Zellsignalisierungsfaktor eingesetzt wird. Vitamin K1 ist essenziell für die Blutgerinnung sowie den Knochen- und Gefäßmetabolismus. Phyllochinon aus grünem Blattgemüse und Pflanzenöl ist die wichtigste Nahrungsquelle von Vitamin K für Menschen.

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Dieser Artikel
95271P1609000BP423
Phytomenadion European Pharmacopoeia (EP) Reference Standard

P1609000

Phytomenadion

Phytomenadion British Pharmacopoeia (BP) Reference Standard

BP423

Phytomenadion

description

viscous liquid

description

BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers

description

European Pharmacopoeia (EP) Reference Standard

description

British Pharmacopoeia (BP) Reference Standard

biological source

synthetic (organic
inorganic)

biological source

synthetic

biological source

synthetic

biological source

-

form

viscous liquid

form

viscous liquid

form

viscous liquid

form

viscous liquid (Clear)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

-

color

, Yellow to Very Dark Yellow to Very Dark Orange

color

light green-yellow to dark green-yellow, light yellow to dark yellow

color

-

color

-

mp

−20 °C (lit.)

mp

−20 °C (lit.)

mp

−20 °C (lit.)

mp

−20 °C (lit.)


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Lagerklasse

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves



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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How much of Vitamin K1 per litre of anaerobic gut-mimicking media is recommended?

    1 answer
    1. This is not an application that is QC tested, but the literature indicates that a good starting point might be 0.5 ug/mL. Please see: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658209/

      Another option would be to use a Vitamin K1 ready-made solution, such as: https://www.sigmaaldrich.com/product/sigma/sbr00053

      This product is at a concentration of 5 mg/mL, but recommends dilution down to 1 ug/mL prior to use, and states that the optimal concentration may vary by strain so, further experimentation may be necessary to determine optimal conditions.

      Helpful?

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