14-920-M
CLK1, active
Sign In to View Organizational & Contract Pricing
Select a Size
14-920
€ 472,00
€ 472,00
Check Cart for Availability
About This Item
UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.41
Skip To
1 of 4
This Item | 14-917-M | SRP5278 | SAB2108770 |
|---|---|---|---|
| biological source human | biological source human | biological source human | biological source rabbit |
| technique(s) activity assay: suitable (kinase) | technique(s) activity assay: suitable (kinase) | technique(s) - | technique(s) - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. - |
| mol wt Mw 45 kDa | mol wt Mw 46 kDa | mol wt ~59 kDa | mol wt 57 kDa |
| Quality Level 100, 300 | Quality Level 100, 300 | Quality Level - | Quality Level - |
| NCBI accession no. | NCBI accession no. | NCBI accession no. | NCBI accession no. |
General description
CLK1 is a dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
Product Source: N-terminal 6His-tagged, recombinant, human CLK1, amino acids 130-end expressed by baculovirus in Sf21 insect cells
Biochem/physiol Actions
Target Sub-Family: CMGC
Packaging
Also available in 250μg size as catalog # 14-920M and in bulk as catalog # 14-920-K.
Physical form
50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol
Purified using immobilized metal affinity chromatography.
Preparation Note
6 months at -70°C
Analysis Note
Routinely evaluated by phosphorylation of peptide ERMRPRKRQGSVRRRV
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Sens. 1
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service