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Merck

559393-M

SB 202190, Hydrochloride

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.

Synonym(s):

SB 202190, Hydrochloride, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride

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1 MG

€ 192,00

€ 192,00

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About This Item

Empirical Formula (Hill Notation):
C20H14FN3O · xHCl
CAS Number:
350228-36-3
Molecular Weight:
331.34 (free base basis)
MDL number:
MFCD28391789
UNSPSC Code:
12352200

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Quality Level

100

Assay

≥97% (HPLC)

form

solid

potency

16 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

amber

solubility

water: 0.5 mg/mL (slightly soluble)
DMSO: soluble

storage temp.

−20°C

SMILES string

Fc1ccc(cc1)c2[nH]c(nc2c4ccncc4)c3ccc(cc3)O.Cl

InChI

1S/C20H14FN3O.ClH/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;/h1-12,25H,(H,23,24);1H

InChI key

XOQSUTIMRLPFPB-UHFFFAOYSA-N

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This Item
559395559388S7076
SB 202190, Hydrochloride A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.

Millipore

559393-M

SB 202190, Hydrochloride

SB 203580, Hydrochloride SB 203580, Hydrochloride, CAS 869185-85-3, is a water-soluble form of SB 203580. A highly potent, selective, ATP-competitive inhibitor of p38 MAP Kinase (IC50 = 34 nM in vitro, 600 nM in cells).

Sigma-Aldrich

559395

SB 203580, Hydrochloride

SB 202190 SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (Ki = 16 nM; IC50 = 350 nM).

Millipore

559388

SB 202190

SB 202190 monohydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

S7076

SB 202190 monohydrochloride hydrate

form

solid

form

solid

form

solid

form

solid

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

desiccated

General description

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).

Biochem/physiol Actions

Target IC50: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)

Preparation Note

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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