Difloxacin hydrochloride

Name: Difloxacin hydrochloride
Brand: SIAL
Price: 70.3 EUR

VETRANAL^®, analytical standard

Synonym(s):

6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid hydrochloride

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100 MG

€ 70,30

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₁₉F₂N₃O₃ · HCl

CAS Number:

91296-86-5

Molecular Weight:

435.85

NACRES:

NA.24

PubChem Substance ID:

329754722

UNSPSC Code:

41116107

MDL number:

MFCD03840489

Key Documents

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Product Name

Difloxacin hydrochloride, VETRANAL^®, analytical standard

InChI

1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H

SMILES string

Cl.CN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)c4ccc(F)cc4

InChI key

JFMGBGLSDVIOHL-UHFFFAOYSA-N

grade

analytical standard

product line

VETRANAL^®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

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Controlled Substances & Illicit Drug Standards

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Show Differences

1 of 4

This Item	N9890	Y0001423	32983
Supelco 33984 Difloxacin hydrochloride	Supelco N9890 Norfloxacin	Y0001423 Difloxacin hydrochloride	Supelco 32983 Enrofloxacin-d₅ hydrochloride
grade analytical standard	grade analytical standard	grade pharmaceutical primary standard	grade analytical standard
format neat	format neat	format neat	format neat
product line VETRANAL^®	product line -	product line -	product line VETRANAL^®
shelf life limited shelf life, expiry date on the label	shelf life -	shelf life -	shelf life limited shelf life, expiry date on the label
technique(s) HPLC: suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) HPLC: suitable, gas chromatography (GC): suitable
application(s) forensics and toxicology pharmaceutical (small molecule)	application(s) clinical testing	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Pharmacokinetics and intramuscular bioavailability of difloxacin in dromedary camels (Camelus dromedarius).

K Abo-El-Sooud et al.

Veterinary journal (London, England : 1997), 179(2), 282-286 (2008-07-08)

Single-dose disposition kinetics of difloxacin (5mg/kg bodyweight) were determined in clinically normal male dromedary camels (n=6) following intravenous (IV) and intramuscular (IM) administration. Difloxacin concentrations were determined by high performance liquid chromatography with fluorescence detection. The concentration-time data were analysed

Effects of cytochrome P450 1A substrate (difloxacin) on enzyme gene expression and pharmacokinetics in crucian carp (hybridized Prussian carp).

Gui Hong Fu et al.

Environmental toxicology and pharmacology, 31(2), 307-313 (2011-07-27)

Cytochrome P450s (CYPs) play a prominent role in drug metabolism and biotransformation which are distributed in liver of aquatic animals. However, limited information is available about CYP genes involved in drug metabolism in fish. In the present study, we explore

In vitro susceptibilities to fluoroquinolones in current and archived Mycoplasma gallisepticum and Mycoplasma synoviae isolates from meat-type turkeys.

Irina Gerchman et al.

Veterinary microbiology, 131(3-4), 266-276 (2008-06-07)

Monitoring of susceptibility to antibiotics in field isolates of pathogenic avian mycoplasmas is important for appropriate choice of treatment. Our study compared in vitro susceptibility to enrofloxacin and difloxacin in recent (2005-2006) isolates of Mycoplasma gallisepticum and Mycoplasma synoviae from

Mutant prevention concentration and phenotypic and molecular basis of fluoroquinolone resistance in clinical isolates and in vitro-selected mutants of Escherichia coli from dogs.

Elias Gebru et al.

Veterinary microbiology, 154(3-4), 384-394 (2011-09-07)

The antibacterial activity, selection of Escherichia coli (E. coli) mutants and mechanisms of fluoroquinolone resistance were investigated by integrating the minimum inhibitory concentration (MIC), mutant prevention concentration (MPC) and in vitro dynamic model approaches. Difloxacin and orbifloxacin, for which the

Pharmacokinetics of difloxacin in pigs and broilers following intravenous, intramuscular, and oral single-dose applications.

H Z Ding et al.

Journal of veterinary pharmacology and therapeutics, 31(3), 200-204 (2008-05-13)

Pharmacokinetics of difloxacin, a fluoroquinolone antibiotic, was determined in pigs and broilers after intravenous (i.v.), intramuscular (i.m.), or oral (p.o.) administration at a single dose of five (pigs) or 10 mg/kg (broilers). Plasma concentration profiles were analyzed by a compartmental

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