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PHR1333
Epigallocatechin gallate
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
(−)-Epigallocatechin gallate, (−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate, (−)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate, EGCG
About This Item
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Product Name
Epigallocatechin gallate, Pharmaceutical Secondary Standard; Certified Reference Material
InChI
1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1
SMILES string
Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c(O)c4
InChI key
WMBWREPUVVBILR-WIYYLYMNSA-N
grade
certified reference material
pharmaceutical secondary standard
agency
traceable to USP 1236700
API family
catechins
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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This Item | E4268 | 324880 | PHL89656 |
|---|---|---|---|
| application(s) pharmaceutical (small molecule) | application(s) metabolomics | application(s) - | application(s) - |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - | technique(s) - |
| Quality Level 300 | Quality Level 200 | Quality Level 100 | Quality Level - |
| grade certified reference material, pharmaceutical secondary standard | grade - | grade - | grade primary reference standard |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. - |
| agency traceable to USP 1236700 | agency - | agency - | agency - |
Analysis Note
Application
General description
Epigallocatechin gallate is a potent polyphenolic flavonoid which is found as a component of tea. It exhibits antioxidant, antimutagenic, antitumor and anti-inflammatory properties, thereby contributing to the health-beneficial actions. It finds potential use as a drug candidate in the pharmaceutical, cosmetic, and nutritional fields.[2]
Other Notes
comparable product
related product
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What is the HPLC purity?
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The purity of this product is reported on an 'as is' basis and is available in the lot specific Certificate of Analysis. A review of recent lots indicates a typical range of 92% - 95%. Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’:
https://www.sigmaaldrich.com/product/sial/phr1333#product-documentationHelpful?
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Is this product suitable for cell culture? Is it permeable to cell membranes?
1 answer-
This product is intended for use as an analytical standard and has not been tested for suitability in cell culture applications. As per available literature, it does appear to be cell permeable, While it is tested against the USP and EP standards, it is not sterile or endotoxin tested.
See the link below for a publication that may be helpful.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9181147/Helpful?
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