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Merck

P9625

Phenazine methosulfate

powder, electron acceptor

Synonym(s):

5-Methylphenazinium methyl sulfate, N-Methylphenazonium methyl sulfate, PMS

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About This Item

Linear Formula:
C13H11N2 · CH3SO4
CAS Number:
299-11-6
Molecular Weight:
306.34
NACRES:
NA.77
PubChem Substance ID:
24899045
UNSPSC Code:
12352200
EC Number:
206-072-1
MDL number:
MFCD00011923
Beilstein/REAXYS Number:
3898869

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Product Name

Phenazine methosulfate,

InChI key

RXGJTUSBYWCRBK-UHFFFAOYSA-M

InChI

1S/C13H11N2.CH4O4S/c1-15-12-8-4-2-6-10(12)14-11-7-3-5-9-13(11)15;1-5-6(2,3)4/h2-9H,1H3;1H3,(H,2,3,4)/q+1;/p-1

SMILES string

COS([O-])(=O)=O.C[n+]1c2ccccc2nc3ccccc13

form

powder

λ

0.01 g/L in H2O, 1 cm path

UV absorption

λ: 387.5 nm Amax

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes
cell membrane | interferes

storage temp.

−20°C

Quality Level

200

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This Item
P45441517006SML3146
Phenazine methosulfate

Sigma-Aldrich

P9625

Phenazine methosulfate

Phenazine ethosulfate ≥95%

Sigma-Aldrich

P4544

Phenazine ethosulfate

Phenelzine sulfate United States Pharmacopeia (USP) Reference Standard

USP

1517006

Phenelzine sulfate

RHPS4 methosulfate ≥98% (HPLC)

Sigma-Aldrich

SML3146

RHPS4 methosulfate

form

powder

form

powder

form

-

form

powder

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

λ

0.01 g/L in H2O, 1 cm path

λ

-

λ

-

λ

-

UV absorption

λ: 387.5 nm Amax

UV absorption

-

UV absorption

-

UV absorption

-

antibiotic activity spectrum

fungi

antibiotic activity spectrum

-

antibiotic activity spectrum

-

antibiotic activity spectrum

-

Application

Phenazine methosulfate is used with ascorbic acid to determine nitric oxide reductase activity.
Phenazine methosulfate has been used:
  • as a component of succinate dehydrogenase enzyme substrate solution[1]
  • to induce superoxide radical generation in red blood cell suspensions and to study its influence on RBC deformability[2]
  • as a component of complex II histochemistry media[3]

Biochem/physiol Actions

Phenazine m ethosulfate (PMS) acts as a good electron acceptor.[4] PMS is reduced non-enzymatically by (nicotinamide adenine dinucleotide) NADH and (nicotinamide adenine dinucleotide phosphate) NADPH.[5]

General description

Phenazines are heterocyclic compounds produced as secondary metabolites by bacteria.[4]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000504481
0000504480
0000504480
0000504481
0000463313

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Assessment of oxidant susceptibility of red blood cells in various species based on cell deformability
Simmonds MJ, et al.
Biorheology, 48(5-6), 293-304 (2011)
Richard Y Wu et al.
Microbiome, 5(1), 135-135 (2017-10-12)
Prebiotics are non-digestible food ingredients that enhance the growth of certain microbes within the gut microbiota. Prebiotic consumption generates immune-modulatory effects that are traditionally thought to reflect microbial interactions within the gut. However, recent evidence suggests they may also impart
María Gabriela Villamizar-Sarmiento et al.
Nanomaterials (Basel, Switzerland), 9(7) (2019-07-03)
We report on the design, development, characterization, and a preliminary cellular evaluation of a novel solid material. This material is composed of low-molecular-weight hyaluronic acid (LMWHA) and polyarginine (PArg), which generate aqueous ionic nanocomplexes (INC) that are then freeze-dried to
Duong Luong et al.
Materials science & engineering. C, Materials for biological applications, 103, 109759-109759 (2019-07-28)
Transition metals (TM) are essential microelements with various biological functions demanded in tissue regeneration applications. Little is known about therapeutic potential of TM within soft hydrogel biomaterials. The soluble divalent TM, such as Zn, Cu, Mn and Co, were stably
Metabolism and function of phenazines in bacteria: impacts on the behavior of bacteria in the environment and biotechnological processes
Pierson LS, et al.
Applied Microbiology and Biotechnology, 86(6), 1659-1670 (2010)
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