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Merck

S4311

L-Serine

98.5-101.0%, suitable for cell culture, non-animal source, meets EP, USP testing specifications

Synonym(s):

L Serine, (S)-2-Amino-3-hydroxypropionic acid

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25 G

€ 137,00

100 G

€ 288,00

1 KG

€ 1.470,00

€ 137,00


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About This Item

Linear Formula:
HOCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
105.09
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-274-3
MDL number:
Beilstein/REAXYS Number:
1721404

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Product Name

L-Serine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

InChI key

MTCFGRXMJLQNBG-REOHCLBHSA-N

InChI

1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1

SMILES string

N[C@@H](CO)C(O)=O

biological source

non-animal source

agency

USP/NF
meets EP testing specifications
meets USP testing specifications

assay

98.5-101.0%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

mp

222 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

application(s)

pharmaceutical (small molecule)

Quality Level

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1 of 4

This Item
PHR1103161250684959
form

powder

form

-

form

-

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

cell culture | mammalian: suitable

assay

98.5-101.0%

assay

-

assay

-

assay

≥99.5% (NT)

Quality Level

300

Quality Level

300

Quality Level

-

Quality Level

200

mp

222 °C (dec.) (lit.)

mp

222 °C (dec.) (lit.)

mp

222 °C (dec.) (lit.)

mp

222 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

solubility

-

solubility

-

solubility

1 M HCl: 0.5 M at 20 °C, clear, colorless

Application

L-Serine has been used as a supplement in a medium to culture Chinese hamster ovary TF 70R cell line and in mouse embryonic fibroblast (MEF)-media.[1][2]

Biochem/physiol Actions

L-Serine is a non-essential amino acid that acts as a precursor for nucleotide synthesis. It has roles in the development and function of the central nervous system.[3]
Precursor of glycine by serine hydroxymethyltransferase.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria
Taru Hilander
Nucleic Acids Research (2018)
Simultaneous environmental manipulations in semi-perfusion cultures of CHO cells producing rh-tPA
Biotechnology (2012)
Abel Lajtha, Simo S. Oja, Pirjo Saransaari, Arne Schousboe
Handbook of Neurochemistry and Molecular Neurobiology: Amino Acids and Peptides in the Nervous System (2007)
Yurena Vivas-García et al.
Molecular cell, 77(1), 120-137 (2019-11-18)
Phenotypic and metabolic heterogeneity within tumors is a major barrier to effective cancer therapy. How metabolism is implicated in specific phenotypes and whether lineage-restricted mechanisms control key metabolic vulnerabilities remain poorly understood. In melanoma, downregulation of the lineage addiction oncogene
Miyoshi Haruta et al.
Science (New York, N.Y.), 343(6169), 408-411 (2014-01-25)
Plant cells are immobile; thus, plant growth and development depend on cell expansion rather than cell migration. The molecular mechanism by which the plasma membrane initiates changes in the cell expansion rate remains elusive. We found that a secreted peptide

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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