Following reconstitution, stock solutions are stable up to 6 months when stored frozen in aliquots at -20°C.
SML0583
Ferrostatin-1
≥95% (HPLC), powder, non-apoptotic cell death inhibitor
Synonym(s):
3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;
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About This Item
Empirical Formula (Hill Notation):
C15H22N2O2
CAS Number:
Molecular Weight:
262.35
UNSPSC Code:
12352200
NACRES:
NA.77
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Product Name
Ferrostatin-1, ≥95% (HPLC)
SMILES string
N(C2CCCCC2)c1c(cc(cc1)C(=O)OCC)N
InChI
1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
InChI key
UJHBVMHOBZBWMX-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
color
, faint purple to brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Related Categories
1 of 4
This Item | F8927 | SML1390 | SML1925 |
|---|---|---|---|
| assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95% (HPLC) |
| form powder | form solid | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear | solubility DMSO: soluble >20 mg/mL, H2O: insoluble | solubility DMSO: 10 mg/mL, clear | solubility H2O: 10 mg/mL, clear |
| color , faint purple to brown | color white | color white to beige | color white to beige |
Application
Biochem/physiol Actions
Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis.
Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.
Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy.[3] Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.[4]
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.
Zilka O, et al.
ACS central science, 3(3), 232-243 (2017)
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Mai T T, et al.
Nature Chemistry, 9(10), 1025-1025 (2017)
The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells.
Kabiraj P, et al.
The Protein Journal, 34(5), 349-358 (2015)
Yimeng Xia et al.
Frontiers in molecular neuroscience, 11, 486-486 (2019-01-29)
The underlying mechanisms of isoflurane neurotoxicity in the developing brain remain unclear. Ferroptosis is a recently characterized form of programmed cell death distinct from apoptosis or autophagy, characterized by iron-dependent reactive oxygen species (ROS) generation secondary to failure of glutathione-dependent
Miao Sui et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 106, 125-133 (2018-06-30)
Ferroptosis is recently reported as a new mode of regulated cell death. It is triggered by disturbed redox homeostasis, overloaded iron and increased lipid peroxidation. Howerver, the role of ferroptosis in hepatic fibrosis remains obscure. In the current study, we
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DMSOで溶解後の保存は冷蔵保存ですか？それとも冷凍保存でしょうか？
1 answer-
Helpful?
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What is the protocol for diluting SML0583 (5 mg), which is said to be soluble in DMSO? Additionally, what kind of stock solution can I prepare for long-term storage and where to store it after adding DMSO.
1 answer-
The solubility of Ferrostatin-1 is approximately 10 mg/ml in DMSO. The detailed solution stability information is not available; therefore, it is recommended to prepare a fresh solution for each application.
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