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Merck

T4264

Tetrahydrozoline hydrochloride

≥98% (HPLC)

Synonym(s):

4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole monohydrochloride, Tetryzoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C13H16N2 · HCl
CAS Number:
522-48-5
Molecular Weight:
236.74
EC Number:
208-329-3
MDL number:
MFCD00058029
UNSPSC Code:
12352200
PubChem Substance ID:
24278736
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

solubility

H2O: freely soluble
alcohol: freely soluble
chloroform: very slightly soluble
diethyl ether: insoluble

originator

Novartis

SMILES string

Cl.C1CC(C2=NCCN2)c3ccccc3C1

InChI

1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H

InChI key

BJORNXNYWNIWEY-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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This Item
1652001Y0000460T6950
Tetrahydrozoline hydrochloride ≥98% (HPLC)

Sigma-Aldrich

T4264

Tetrahydrozoline hydrochloride

Tetrahydrozoline hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1652001

Tetrahydrozoline hydrochloride

Tetrahydrozoline hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0000460

Tetrahydrozoline hydrochloride

Tizanidine hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

T6950

Tizanidine hydrochloride

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

100

solubility

H2O: freely soluble, chloroform: very slightly soluble, alcohol: freely soluble, diethyl ether: insoluble

solubility

-

solubility

-

solubility

H2O: >20 mg/mL

originator

Novartis

originator

-

originator

-

originator

Acorda Therapeutics

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Biochem/physiol Actions

Tetrahydrozoline is an α-adrenergic agonist and an imidazoline derivative.[1][2] It plays a crucial role in the constriction of conjunctival blood vessels.[2] Tetrahydrozoline is a common component of nasal and eye drop formulations.[2]

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000493073
0000493073
0000436956
0000436956
SLCB7381

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Matthew E Stillwell et al.
Forensic science international, 221(1-3), e12-e16 (2012-05-05)
We report two cases of drug-facilitated sexual assault which presented with CNS depression rendering the victims vulnerable to sexual assault and unable to recall the events surrounding the crimes. In each tetrahydrozoline (THZ) was quantified. Case #1 ingested an unknown
Luciano Giardino et al.
Journal of endodontics, 33(7), 852-855 (2007-09-07)
The aim of this study was to compare the antimicrobial efficacy of 5.25% NaOCl, BioPure MTAD (Dentsply Tulsa Dental, Johnson City, TN), and Tetraclean (Ogna Laboratori Farmaceutici, Milano, Italy) against Enterococcus faecalis biofilm generated on cellulose nitrate membrane filters. After
Engin Bilge Ozgurhan et al.
BioMed research international, 2013, 481843-481843 (2013-07-19)
To evaluate the effect of a fluorometholone/tetrahydrozoline fixed combination on conjunctival graft morphology after primary pterygium excision. The patients who underwent pterygium excision with conjunctival autograft transplantation were randomized into three groups based on postoperative medications as the fluorometholone/tetrahydrozoline group
Aaron Daggy et al.
Veterinary and human toxicology, 45(4), 210-212 (2003-07-29)
Visine, an over-the-counter, tetrahydrozoline topical ophthalmic decongestant, possesses central and peripheral alpha2-adrenergic properties. We present a case of accidental pediatric oral exposure with resultant neurological and cardiovascular complications. Visine is not marketed in childproof containers, despite the potential severity of
Igor Kopac et al.
The International journal of prosthodontics, 15(1), 14-19 (2002-03-13)
The aim of this in vivo study on dogs was to investigate and compare the inflammatory potential of four different retraction agents on the gingival connective tissue. All procedures on eight beagle dogs were performed under general anesthesia: taking oral
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