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QuEChERS Cleanup and Analysis of Veterinary Drugs in Milk by LC/MS/MS

Use QuEChERS methods to analyze samples of milk for veterinary drugs.

Replace Classical Liquid-Liquid Extractions with EXtrelut^® NT

Simplify your liquid-liquid extractions with our emulsion-free supported-liquid extraction (SLE) single step solution.

Quick, Sensitive LC/MS/MS Analysis of Aflatoxins in Cannabis

Analyte recovery values from spiked cannabis extracts ranged from 102 to 127% with RSD below 12% for 3 replicates. Excellent recovery values were even observed for Aflatoxins B2 and G2 which were spiked at a low level of 6.1 ppb.

Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum

Novel sample prep technique coupled with the unique selectivity of the Ascentis Express F5 column enables a fast and simplified bioanalytical method for associated vitamin D metabolites.

Mixed-Mode SPE Improves Extraction of Pharmaceutical Compounds from Biological Fluids

Ion-Exchange SPE Methodology

Solid Phase Extraction Microbiology requires polar analytes introduced in a non-polar sample or mobile phase.

Solid Phase Extraction: Reversed-Phase Methodology

Reversed-phase interaction will retain most molecules with hydrophobic character; it is very useful for extracting analytes that are very diverse in structure within the same sample.

Two Distinct Sample Prep Approaches to Overcome Matrix Effect in LC/MS of Serum or Plasma Samples

This article highlights the impact that sample matrix effects can have on LC/MS response and discusses two novel approaches to reduce it.

The Extraction of Amphetamine and Related Drugs using Molecularly Imprinted Polymer SPE

Automated Solid Phase Microextraction (SPME) Sampling

Use the full range of Supelco® SPME fibers with your PAL autosampler system so you can sample smarter

Rugged SPME Sampling

SPME fibers with CAR/PDMS and PDMS/DVB coatings on nitinol core assembly enhance fiber performance for solid phase microextraction.

SPME Fiber Performance Tips for Volatiles & Semi-Volatiles

Enhance the extraction capability of Supelco SPME fibers for the collection of volatiles, semi-volatiles and polar compounds. spme

Analysis of Pesticides in Baby Food by Solid Phase Microextraction (SPME) Using a New Overcoated Fiber

A direct immersion SPME method using a new overcoated SPME fiber was developed for the extraction of pesticides from pureed prune baby food.

Protein Binding Determination - Comparison Study of Techniques & Devices

Comparative analysis of Supel™ BioSPME 96-Pin device with a rapid equilibrium dialysis technique for accuracy of measured values, sample cleanliness, and workflow time in drug protein binding.

Speed, Simplicity and Accuracy of Protein Binding Determination using BioSPME

Learn about Supel™ BioSPME C18 high-throughput devices to determine plasma protein binding and decrease the sample preparation time to less than an hour.

Resolves Difficult Sample Matrix Problems

In the flavor and fragrance industry, analytical chemists are often required to isolate key ingredients, off-flavor components, or trace organic compounds from their sample matrices without altering their structure or composition.

High-Performance Thin-Layer Chromatography: A Fast and Efficient Fingerprint Analysis Method for Medicinal Plants

In this article we present several HPTLC applications and analytical standards for ginsenosides.

High Performance Thin Layer Chromatography Plates

HPTLC plates provide superior separation, speed, and sensitivity, making them ideal for advanced qualitative and quantitative analysis.

Identification of fixed oils by Thin layer chromatography

This application note describes the HPTLC-based identification of fixed oils using octadecyl silyl silica gel as the coating substance, following USP 43 NF 38 monograph method containing USP general chapter .

Sildenafil Citrate USP Method Using HPTLC Plates for the Limit of Imidazole Test

In the present study we demonstrate compliance of silica gel 60 F254 HPTLC plates with USP requirements, and how HPTLC plates are suitable for the Sildenafil citrate-Limit of Imidazole test.

Tips & Tricks for Thin-Layer Chromatography

Thin Layer Chromatography Troubleshooting: This article details TLC tips and tricks that one must consider while performing different steps of the technique.

Titrisol^® Concentrates

Discover more sustainable Titrisol® concentrates available in small HDPE bottles that are easy to use and designed to reduce lab waste.

Electrochemistry on the Bench and in the Field

Nanomaterials, electrochemistry, BASi, LIB, Lithium Ion Batteries, reference electrode, Teflon, silver nitrate, working electrodes, counter electrode, organic electrosynthesis

Selectophore Ionophores

Sigma-Aldrich.com presents an article on Selectophore Ionophores

Attachment Factors for Three-dimensional Cell Culture

The extracellular matrix (ECM) and its attachment factor components are discussed in this article in relation to their function in structural biology and their availability for in vitro applications.

Bioink Selection for 3D Bioprinting

Bioinks enable 3D bioprinting of tissue constructs for drug screening and transplantation; select suitable bioinks for specific tissue engineering.

Advanced Cell Culture Technology for Generation of In Vivo-like Tissue Models

Sophisticated models are developing as 3D cell culture technology becomes established and accepted as a means of creating more physiologically relevant cell-based assays.

3D Cell Culture Tools and Techniques

3D cell culture overview. Learn about 2D vs 3D cell culture, advantages of 3D cell culture, and techniques available to develop 3D cell models

Co-culture of Tumor and Stromal Cells in TrueGel3D™ Hydrogels

TrueGel3D™ synthetic hydrogel can be used to study co-culture of tumor and stromal cells.

CytoSoft^® Modulus Plates for Cell Culture

CytoSoft® modulus plates analyze substrate stiffness effects on cell behavior across a physiological range for mechanobiology research.

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