- A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
Organic letters (2014-06-17)
Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li
PMID24933098
ABSTRACT
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
MATERIALS
Product Number
Brand
Product Description
Copper, tube, 1000mm, outside diameter 0.25mm, inside diameter 0.05mm, wall thickness 0.1mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 6.35mm, inside diameter 4.93mm, wall thickness 0.71mm, as drawn, 99.9%
Copper, wire reel, 1000m, diameter 0.1mm, annealed, 99.9%
Copper, wire reel, 50m, diameter 0.5mm, annealed, silver plated, 99.9%
Copper, wire reel, 25m, diameter 0.5mm, as drawn, 99.98+%
Copper, wire reel, 50m, diameter 0.05mm, as drawn, 99.99+%
Copper, wire reel, 50m, diameter 0.125mm, annealed, 99.9%
Copper, wire reel, 20m, diameter 0.05mm, as drawn, 99.99+%
Copper, wire reel, 50m, diameter 1.0mm, as drawn, 99.98+%
Copper, wire reel, 10m, diameter 0.025mm, as drawn, 99.99+%
Copper, wire reel, 100m, diameter 0.02mm, annealed, 99.99%
Copper - O.F.H.C., foil, light tested, 300x300mm, thickness 0.05mm, hard, 99.95+%
Copper, wire reel, 5m, diameter 0.75mm, as drawn, 99.98+%
Copper - O.F.H.C., rod, 1000mm, diameter 12.7mm, as drawn, 99.95+%
Copper, wire reel, 50m, diameter 1.0mm, annealed, 99.9%
Copper - O.F.H.C., foil, light tested, 50x50mm, thickness 0.025mm, hard, 99.95+%
Copper, tube, 100mm, outside diameter 4.0mm, inside diameter 3.2mm, wall thickness 0.4mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 4mm disks, thickness 0.25mm, annealed, 99.95+%
Copper - O.F.H.C., foil, 2m coil, thickness 0.1mm, coil width 100mm, hard, 99.95+%
Copper - O.F.H.C., foil, 150x150mm, thickness, 0.5mm, half hard, flattened, 99.95+%
Copper - O.F.H.C., foil, 15mm disks, thickness 0.1mm, hard, 99.95+%
Copper - O.F.H.C., foil, 1m coil, thickness 0.05mm, annealed, 99.95+%
Copper - O.F.H.C., foil, 15mm disks, thickness 0.25mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.1mm, hard, 99.95+%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.125mm, hard, 99.95+%
Copper - O.F.H.C., foil, 5m coil, thickness 0.010mm, coil width 25mm, hard, 99.95+%
Copper, tube, 500mm, outside diameter 3.5mm, inside diameter 1.56mm, wall thickness 0.97mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 4mm disks, thickness 0.25mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 1m coil, thickness 0.05mm, coil width 300mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 2m coil, thickness 0.1mm, half hard, 99.95+%