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Merck

GRM6

glutamate receptor, metabotropic 6

Sinônimos:
CSNB1B, GPRC1F, MGLUR6, mGlu6
Espécies:
Human GRM6 (2916), Mouse Grm6 (108072), Rat Grm6 (24419), domestic guinea pig Grm6 (100722389), naked mole-rat Grm6 (101717017), cow GRM6 (529656), domestic cat GRM6 (101097449), dog GRM6 (481452)
ID UniProtKB:
O15303
ID do gene:
  • Human(2916) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]
  • Mouse(108072) glutamate receptor, metabotropic 6
  • Rat(24419) glutamate receptor, metabotropic 6
  • domestic guinea pig(100722389) glutamate receptor, metabotropic 6
  • naked mole-rat(101717017) glutamate receptor, metabotropic 6
  • cow(529656) glutamate receptor, metabotropic 6
  • domestic cat(101097449) glutamate receptor, metabotropic 6
  • dog(481452) glutamate receptor, metabotropic 6

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Small Molecule - Agonist

Número do produto
Descrição
Espécies
A7400
D-2-Aminoadipic acid, ,
Espécies
rat
A7275
L-2-Aminoadipic acid, ≥98% (TLC),
Espécies
rat, human
A155
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Espécies
human
A7929
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Espécies
rat, human
A0326
(S)-AMPA, ≥97%,
Espécies
mouse, human, rat

Small Molecule - Antagonist

Número do produto
Descrição
Espécies
A7400
D-2-Aminoadipic acid, ,
Espécies
rat
A4910
DL-2-Amino-3-phosphonopropionic acid, ,
Espécies
human
A0326
(S)-AMPA, ≥97%,
Espécies
mouse, human, rat
G1251
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Espécies
rat, human
G8415
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Espécies
rat, human

Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
SAB4501324
Anti-MGLUR6 antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
ELISA
immunohistochemistry
western blot
HPA014511
Anti-GRM6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reatividade de espécies
human
Aplicação
immunohistochemistry

Small Molecule - Mixed Agonist/Antagonist

Número do produto
Descrição
Espécies
A7929
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Espécies
rat, human
G1251
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Espécies
rat, human
G8415
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Espécies
rat, human
49449
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Espécies
rat, human
W328502
L-Glutamic acid, FCC,
Espécies
rat, human

esiRNA

Número do produto
Descrição
Espécies
EHU140761
MISSION® esiRNA, targeting human GRM6,
Espécies
human
EMU053921
MISSION® esiRNA, targeting mouse Grm6,
Espécies
mouse