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[Home](https://www.sigmaaldrich.com/CA/en)[Polymerase Chain Reaction Applications](https://www.sigmaaldrich.com/CA/en/applications/genomics/pcr)Proligo® Manufacturing Site - Hamburg
# Oligonucleotide Reagents Manufacturing Site - Hamburg
## State-of-the-Art Production
The Oligonucleotide reagents manufacturing site in Hamburg, Germany is designed as a multi-purpose facility with built-in flexibility and the capability to manufacture a complex mix of products to suit a variety of customer needs.
DNA and RNA phosphoramidites are manufactured in glass-lined reactors and purified by preparative column chromatography on silica gel with medium-to-high pressure chromatography equipment.
The Hamburg facility has the flexibility to prepare and purify alternative mixes of high volume standard products as well as small-scale specialties.
## Take a Tour of the Production Site
### Hamburg facility at a glance:
__Process Technology and R&D__
- 3 labs dedicated to R&D and PT
- Scale from mg to kg
__Production and Purification__
- Lab production up to __20L reaction__ volume
- Bulk production up to __2500L reaction__ volume
- 3 automated prep. HPLC with 10 to 45 cm column diameter
- >__12.000 kg/year__ amidite purification capacity
- Capacity increasing annually
__Finished Goods__
- 250 bulk products, 910 finished products, custom capabilities
- Dedicated powder filling department and production unit for liquid products
__Quality__
- 3 labs dedicated for QC and analytical development
## MOST EXPERIENCED AMIDITE MANUFACTURER IN THE MARKET
Over 40 years’ experience in the manufacture of Oligonucleotide reagents:
- Phosphoramidites
- Liquid reagents including bulk returnable drums
- CPG
Annual amidite production capacity is more than __12 tons and increasing annually__, to meet the growing industry demands. All __critical raw materials are dual sourced__ to ensure continuity of supply
Hamburg, Germany
Telephone: +49-40-797-02-250
[Email](mailto:deuham-cs@merckgroup.com)
### Contact Us
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