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E4642
(±)-Epinephrine hydrochloride
≥98% (TLC), powder, adrenergic receptor agonist
Synonym(e):
(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
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Über diesen Artikel
Empirische Formel (Hill-System):
C9H13NO3 · HCl
CAS-Nummer:
Molekulargewicht:
219.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-346-0
MDL number:
Quality level:
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Unterstützung erhaltenProduktname
(±)-Epinephrine hydrochloride,
InChI key
ATADHKWKHYVBTJ-UHFFFAOYSA-N
InChI
1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
SMILES string
OC(CNC)C1=CC=C(O)C(O)=C1.Cl
solubility
H2O: 50 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)
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Verwandte Kategorien
1 of 4
Dieser Artikel | E4375 | PHR1509 | E4250 |
|---|---|---|---|
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-30°C | storage temp. 2-8°C |
| solubility H2O: 50 mg/mL | solubility H2O: soluble, alcohol: soluble | solubility - | solubility - |
| Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155) | Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155) | Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155) | Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155) |
Application
(±)-Epinephrine hydrochloride has been used:
- in the induction of renalase expression in Human renal proximal tubular epithelial cells[1]
- in the infusion studies to test its effect on heart rate and eye temperature measurements in bull[2]
- as a medium supplement for the stimulation of endothelial progenitor cells[3]
Biochem/physiol Actions
Adrenergic receptor agonist.
Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility.[4] It is used in the treatment of acute anaphylaxis.[5] Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.[6]
General description
Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system.[7] It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors.[8] Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.[4]
Other Notes
The ratio of +/- adrenaline is not determined.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Lagerklasse
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Sympathetic predominance is associated with impaired endothelial progenitor cells and tunneling nanotubes in controlled-hypertensive patients
de Cavanagh EAMV, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 307, H207?H215-H207?H215 (2014)
Advantages and disadvantages of adrenaline in regional anaesthesia
Niemi G
Best Practice & Research. Clinical Anaesthesiology, 19(2), 229-245 (2005)
Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT
Martin JL, et al.
Structure, 9(10), 977-985 (2001)
Effects of an epinephrine infusion on eye temperature and heart rate variability in bull calves
Stewart M, et al.
Journal of Dairy Science, 93(11), 5252-5257 (2010)
Adrenaline, cardiac arrest, and evidence based medicine.
Rainer TH and Robertson CE
Emergency Medicine Journal : EMJ, 13(4), 234-237 (1996)
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est ce que l'epinephrine de degrade a 37C et est ce qu'il est reversible?
1 answer-
Helpful?
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Can it be stored at -20C
1 answer-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
Helpful?
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Hi, Do you have the ratio/ amount of D- and L-adrenaline in this product?
1 answer-
The ratio of +/- adrenaline is not determined.
Helpful?
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