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Merck

235989

Brij® L4

average Mn ~362

Synonym(s):

Polyethylene glycol dodecyl ether, Polyoxyethylene (4) lauryl ether

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About This Item

Linear Formula:
(C20H42O5)n
CAS Number:
9002-92-0
NACRES:
NA.21
PubChem Substance ID:
24854130
UNSPSC Code:
12161900
MDL number:
MFCD00043063

Key Documents

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Product Name

Brij® L4, average Mn ~362

InChI

1S/C20H42O5/c1-2-3-4-5-6-7-8-9-10-11-13-22-15-17-24-19-20-25-18-16-23-14-12-21/h21H,2-20H2,1H3

SMILES string

CCCCCCCCCCCCOCCOCCOCCOCCO

InChI key

WPMWEFXCIYCJSA-UHFFFAOYSA-N

description

non-ionic

form

solid or liquid

mol wt

average Mn ~362

impurities

≤1% Water

refractive index

n20/D 1.451 (lit.)

mp

48 °C

solubility

water: insoluble

density

0.95 g/mL at 25 °C (lit.)

HLB

9

Quality Level

200

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1 of 4

This Item
16005P1254B4184
Brij® L4 average Mn ~362

Sigma-Aldrich

235989

Brij® L4

Brij® L23 main component: tricosaethylene glycol dodecyl ether

Sigma-Aldrich

16005

Brij® L23

Brij® L23 suitable for Stein-Moore chromatography

Sigma-Aldrich

P1254

Brij® L23

Brij® L23 solution 30 % (w/v) in H2O

Sigma-Aldrich

B4184

Brij® L23 solution

mol wt

average Mn ~362

mol wt

-

mol wt

micellar avg mol wt 48,000, estimated mol wt 1198

mol wt

~1198.0 g/mol

HLB

9

HLB

-

HLB

16.9

HLB

16.9

density

0.95 g/mL at 25 °C (lit.)

density

-

density

-

density

1.024 g/mL

description

non-ionic

description

non-ionic

description

non-ionic

description

non-ionic

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

refractive index

n20/D 1.451 (lit.)

refractive index

-

refractive index

-

refractive index

-

Application

Brij® L4 has been used:
  • as a surfactant for the synthesis of copper(I) oxide (Cu2O) spherical nanoparticles using a microemulsion technique[1]
  • as a non-ionic surfactant for preparing reverse micelles to synthesize Pt3Co alloy nanoparticles[2]
  • as a surfactant to enhance the efficiency of interfacial coupling of hydrophobic materials and to make hydrogel[3]

Biochem/physiol Actions

Brij® L4 exhibits amphiphilic properties.[4] Brij L4 contains hydrophobic and hydrophilic regions that can form micelles and disperse hydrophobic drugs into the core of micelles. This in turn enhances drug solubility. Brij L4 also elicits a strong inhibitory effect against breast cancer resistance protein (BCRP) mediated drug efflux.[4] It inhibits Taq adsorption better when compared to other commonly used surfactants. Brij L4 supports droplet polymerase chain reaction (PCR) in picoliter reaction volumes at standard Taq concentrations.[5]

General description

Brij® L4 is a non-ionic surfactant. It comprises an alkyl (C12) tail attached to an oxyethylene headgroup.[5]

Legal Information

Brij is a registered trademark of Croda International PLC

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX8039
MKCV8516
MKCQ7698
MKCL6849
MKCK4613

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Copper (i) oxide nanoparticle-mediated C-C couplings for synthesis of polyphenylenediethynylenes: Evidence for a homogeneous catalytic pathway
Pary FF, et al.
Catalysis Science & Technology, 11(7), 2414-2421 (2021)
Paul Le Floch et al.
ACS applied materials & interfaces, 9(30), 25542-25552 (2017-07-12)
The emergence of stretchable electronics and its potential integration with textiles have highlighted a challenge: Textiles are wearable and washable, but electronic devices are not. Many stretchable conductors have been developed to enable wearable active textiles, but little has been
Albert-Adrien Ramelet
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 38(5), 748-751 (2012-01-25)
Some leg telangiectasias may be refractory to treatment, including sclerotherapy and lasers. To describe the innovative Sclerotherapy in Tumescent Anesthesia of Reticular veins and Telangiectasias (START) approach to achieving good results in such patients, which also proves effective in treating
Ramon R J P van Eekeren et al.
Journal of vascular surgery, 57(2), 445-450 (2012-11-13)
Thermal ablative techniques of varicose veins carry a risk of heat-related complications, including postoperative pain. Mechanochemical endovenous ablation (MOCA) might avoid these complications and reduce postoperative pain because of the absence of thermal energy. This study evaluated postoperative pain and
G C Valenzuela et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 46(5), 593-599 (2013-09-28)
Sclerosant foams are aqueous and break down under the influence of gravity, pressure, and temperature. The aim of this study was to investigate the effects of temperature on foam stability. Sodium tetradecyl sulphate (STS) and polidocanol (POL) liquid and foam
View All Related Papers

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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