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Merck

C7731

Caffeine

meets USP testing specifications, anhydrous

Synonym(s):

1,3,7-Trimethylxanthine

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250 G

CHF 291.00

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CHF 892.00

CHF 291.00

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About This Item

Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
58-08-2
Molecular Weight:
194.19
UNSPSC Code:
12352210
NACRES:
NA.21
PubChem Substance ID:
24892984
EC Number:
200-362-1
Beilstein/REAXYS Number:
17705
MDL number:
MFCD00005758
Grade:
anhydrous
Agency:
USP/NF
meets USP testing specifications

Key Documents

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Product Name

Caffeine, meets USP testing specifications, anhydrous

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

grade

anhydrous

agency

USP/NF
meets USP testing specifications

form

crystalline
powder

mp

234-236.5 °C (lit.)

solubility

H2O: soluble 18.7 g/L at 16 °C

Quality Level

200

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

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1 of 4

This Item
27602PHL89591C-051
Caffeine meets USP testing specifications, anhydrous

Sigma-Aldrich

C7731

Caffeine

Caffeine anhydrous, tested according to Ph. Eur.

Sigma-Aldrich

27602

Caffeine

Caffeine phyproof® Reference Substance

PHL89591

Caffeine

Caffeine solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

C-051

Caffeine solution

grade

anhydrous

grade

anhydrous

grade

primary reference standard

grade

certified reference material

agency

USP/NF, meets USP testing specifications

agency

EPA 1694, USP/NF, tested according to Ph. Eur.

agency

-

agency

-

mp

234-236.5 °C (lit.)

mp

234-236.5 °C (lit.)

mp

234-236.5 °C (lit.)

mp

-

form

crystalline

form

powder

form

-

form

liquid

solubility

H2O: soluble 18.7 g/L at 16 °C

solubility

H2O: soluble 18.7 g/L at 16 °C

solubility

-

solubility

-

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

300

Application

Caffeine has been used:
  • to functionally disable Ca2+ removal via sarco/endoplasmic reticulum Ca2+ ATPase (SERCA)[1]
  • to determine its effects in overcoming excitation-contraction-coupling failure[2]
  • to compare its role as a stimulant with guarana[3]

General description

Caffeine is a commonly consumed pharmacologically active substance. It is a member of the class of methylxanthines.[4] It is a natural alkaloid found in coffee, cocoa and other plants. Caffeine might be linked to osteoporosis, cardiovascular risk, arrhythmia and gastrointestinal disturbances.[5] Caffeine is used to treat orthostatic hypotension,[6] bronchopulmonary dysplasia and apnea of prematurity (AOP).[7]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000490122
0000490122
0000517926
0000517927
0000517927

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Caffeine?s beneficial effect on maximal voluntary strength and activation in uninjured but not injured muscle
Park ND, et al.
International Journal of Sport Nutrition and Exercise Metabolism, 18(6), 639-652 (2008)
There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes
Devenyi RA and Sobie EA
Journal of Molecular and Cellular Cardiology, 96, 38-48 (2016)
Orthostatic hypotension in the elderly: diagnosis and treatment
Gupta V and Lipsitz LA
The American Journal of Medicine, 120(10), 841-847 (2007)
Ryan A Devenyi et al.
Journal of molecular and cellular cardiology, 96, 38-48 (2015-08-04)
While many ion channels and transporters involved in cardiac cellular physiology have been identified and described, the relative importance of each in determining emergent cellular behaviors remains unclear. Here we address this issue with a novel approach that combines population-based
Effects of caffeine on human health
Nawrot P, et al.
Food Additives and Contaminants, 20(1), 1-30 (2003)
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