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D1387

P1,P3-Di(adenosine-5′) triphosphate ammonium salt

solid

Synonym(s):

A(5′)P3(5′)A, Diadenosine triphosphate

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10 MG

CHF 311.00

25 MG

CHF 645.00

CHF 311.00

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About This Item

Linear Formula:
C20H24N9O16P3 · NH3
CAS Number:
102783-40-4
Molecular Weight:
756.41
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24893423
NACRES:
NA.51
MDL number:
MFCD00058130

Key Documents

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Product Name

P1,P3-Di(adenosine-5′) triphosphate ammonium salt,

SMILES string

N.Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(=O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)C(O)C3O

InChI

1S/C20H27N10O16P3.H3N/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(43-19)1-41-47(35,36)45-49(39,40)46-48(37,38)42-2-8-12(32)14(34)20(44-8)30-6-28-10-16(22)24-4-26-18(10)30;/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H2,21,23,25)(H2,22,24,26);1H3

InChI key

PKSQTRWRSNNYCW-UHFFFAOYSA-N

form

solid

impurities

Other adenosine phosphates, essentially free

storage temp.

−20°C

Quality Level

200

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P1,P3-Di(adenosine-5′) triphosphate ammonium salt

Sigma-Aldrich

D1387

P1,P3-Di(adenosine-5′) triphosphate ammonium salt

P1,P4-Di(adenosine-5′) tetraphosphate ammonium salt ≥95% (HPLC), powder

Sigma-Aldrich

D1262

P1,P4-Di(adenosine-5′) tetraphosphate ammonium salt

P1,P5-Di(adenosine-5′) pentaphosphate trilithium salt ≥95%, powder

Sigma-Aldrich

D6392

P1,P5-Di(adenosine-5′) pentaphosphate trilithium salt

P1,P5-Di(adenosine-5′) pentaphosphate ammonium salt ≥95% (HPLC), powder

Sigma-Aldrich

D8013

P1,P5-Di(adenosine-5′) pentaphosphate ammonium salt

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

solid

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

impurities

Other adenosine phosphates, essentially free

impurities

-

impurities

-

impurities

-

Application

P1,P3-Di(adenosine-5′) triphosphate (Ap3A) is a diadenosine oligophosphate (ApnA) family member. ApnAs have been found to act as a signaling molecule.
P1,P3-Di(adenosine-5′) triphosphate ammonium salt has been used as a component of the incubation medium for incubating fibroblast cell lines for FoF1 ATP-synthase activity.[1]

Preparation Note

Approx. 25 A260 units per mg.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000284405
0000284405
113F7275
101K7019
079H5956

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A S Mildvan et al.
Archives of biochemistry and biophysics, 433(1), 129-143 (2004-12-08)
Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other moieties, X, and contain the sequence motif or Nudix box, GX(5)EX(7)REUXEEXGU. The mechanisms of Nudix hydrolases are highly diverse in the position on the substrate at which nucleophilic substitution
Alan R Conant et al.
Vascular pharmacology, 48(4-6), 157-164 (2008-03-08)
Diadenosine polyphosphates (Ap(n)A) are released by degranulating platelets and high, local concentrations may form at sites of platelet activation. Radial artery grafts, now often used alongside the internal mammary artery in coronary artery bypass surgery, are particularly reactive to several
Brigitte Maria Stavrou
Current medicinal chemistry. Cardiovascular and hematological agents, 1(2), 151-169 (2004-08-24)
Diadenosine polyphosphates (Ap(n)A) are naturally occurring molecules which have been identified in human and guinea-pig cardiac tissue and whose physiological role is being established. They are stored in platelet dense granules in a metabolically inactive form. Ap(n)A form a class
Michael Wright et al.
The FEBS journal, 273(15), 3534-3544 (2006-08-04)
Heat shock inducible lysyl-tRNA synthetase of Escherichia coli (LysU) is known to be a highly efficient diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) synthase. However, we use an ion-exchange HPLC technique to demonstrate that active LysU mixtures actually have a dual catalytic activity, initially
Manuela Campiglio et al.
Journal of cellular physiology, 208(2), 274-281 (2006-03-21)
FHIT is a tumor suppressor gene that is frequently inactivated in human cancer. Although the Fhit protein is known to hydrolyze diadenosine triphosphate (Ap(3)A), this hydrolase activity is not required for Fhit-mediated oncosuppression. Indeed, the molecular mechanisms and the regulatory
View All Related Papers

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