L1663

Lidocaine N-ethyl chloride

Name: Lidocaine N-ethyl chloride
Brand: SIGMA
Price: 413 CHF

sodium channel blocker

Synonym(s):

N-(2,6-Dimethylphenylcarbamoylmethyl) triethylammonium chloride

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₇N₂OCl

CAS Number:

5369-03-9

Molecular Weight:

298.85

UNSPSC Code:

12352200

PubChem Substance ID:

24896288

NACRES:

NA.77

MDL number:

MFCD01669894

Quality level:

100

Storage condition:

protect from light

Key Documents

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Product Name

Lidocaine N-ethyl chloride,

storage condition

protect from light

Quality Level

100

solubility

H₂O: soluble

storage temp.

room temp

SMILES string

[Cl-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H

InChI key

LLPPOMUAOGMYQI-UHFFFAOYSA-N

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Bioactive Small Molecules

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Show Differences

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This Item	SML1444	C4382	D2926
Sigma-Aldrich L1663 Lidocaine N-ethyl chloride	Sigma-Aldrich SML1444 (±)-Mepivacaine hydrochloride	Sigma-Aldrich C4382 Carbamoylcholine chloride	D2926 Diphenyleneiodonium chloride
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 300
storage temp. room temp	storage temp. room temp	storage temp. -	storage temp. room temp
solubility H₂O: soluble	solubility H₂O: 20 mg/mL, clear	solubility H₂O: 1 g/mL, ethanol: 20 mg/mL	solubility DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
storage condition protect from light	storage condition desiccated	storage condition -	storage condition -

Biochem/physiol Actions

Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.

Other Notes

Stable at room temperature lyophilized. In solution, store at 4 °C for up to two weeks. Store solutions at -20 °C for up to six months.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Co-Application of Eugenol and QX-314 Elicits the Prolonged Blockade of Voltage-Gated Sodium Channels in Nociceptive Trigeminal Ganglion Neurons.

Sung-Min Hwang et al.

Biomolecules, 10(11) (2020-11-11)

Local anesthetics (LAs) can completely block nociception by inhibiting voltage-gated sodium channels (VGSCs), and thus, blocking action potentials (APs) within sensory neurons. As one of the several LAs, eugenol is used for dental pain treatment. It reportedly features multiple functions

BDNF-induced presynaptic facilitation of GABAergic transmission in the hippocampus of young adults is dependent of TrkB and adenosine A2A receptors.

Mariana Colino-Oliveira et al.

Purinergic signalling, 12(2), 283-294 (2016-02-22)

Brain-derived neurotrophic factor (BDNF) and adenosine are widely recognized as neuromodulators of glutamatergic transmission in the adult brain. Most BDNF actions upon excitatory plasticity phenomena are under control of adenosine A2A receptors (A2ARs). Concerning gamma-aminobutyric acid (GABA)-mediated transmission, the available

Asymmetry between ON and OFF α ganglion cells of mouse retina: integration of signal and noise from synaptic inputs.

Michael A Freed

The Journal of physiology, 595(22), 6979-6991 (2017-09-16)

Bipolar and amacrine cells presynaptic to the ON sustained α cell of mouse retina provide currents with a higher signal-to-noise power ratio (SNR) than those presynaptic to the OFF sustained α cell. Yet the ON cell loses proportionately more SNR

Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray.

Vijay K Samineni et al.

Nature communications, 10(1), 4356-4356 (2019-09-27)

Itch is a distinct aversive sensation that elicits a strong urge to scratch. Despite recent advances in our understanding of the peripheral basis of itch, we know very little regarding how central neural circuits modulate acute and chronic itch processing.

Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons.

Andrew W Baxter et al.

The European journal of neuroscience, 34(2), 213-220 (2011-07-14)

P2X4 receptors are calcium-permeable cation channels gated by extracellular ATP. They are found close to subsynaptic sites on hippocampal CA1 neurons. We compared features of synaptic strengthening between wild-type and P2X4 knockout mice (21-26 days old). Potentiation evoked by a

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Global Trade Item Number

SKU	GTIN
L1663-500MG	04061832574783
L1663-1G	04061826226247

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Lidocaine N-ethyl chloride