O0884

Monoclonal Anti-Oncostatin M antibody produced in mouse

clone 17001, purified immunoglobulin, lyophilized powder

• Synonym(s): Anti-OSM
• EC Number: 202-739-6
• MDL number: MFCD01092430
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 17001, monoclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): indirect ELISA: suitable; neutralization: suitable; western blot: suitable
• isotype: IgG2a
• UniProt accession no.: P13725
• storage temp.: −20°C
• Gene Information: human ... OSM(5008)

Description

General description

Oncostatin M (OSM) is a growth-regulating cytokine produced by the activated T lymphocytes and macrophages. It has a pivotal role in stimulating the production of IL-6 in cultured human endothelial cells[1]. It also facilitates the LDL receptor expression and its uptake by hepatoma cells[2]. Further, OSM can induce synovial fibroblast-like cells to produce urokinase type plasminogen activator[3]. Monoclonal anti-Oncostatin M antibody can be used for neutralizing the biological activity of rhOSM on the human TF-1 cell line[4]. Mouse anti-Oncostatin M antibody reacts specifically with recombinant human OSM. The product has shown no cross-reactivity with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Specificity

The antibody neutralizes the biological activity of recombinant human OSM. Does not cross-react with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Immunogen

recombinant human OSM expressed in Escherichia coli.

Application

Monoclonal anti-Oncostatin M antibody can be used in western blotting and capture ELISA.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (PBS) with 5% trehalose.

Preparation Note

Purified using protein A.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves