Merck
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O0884

Sigma-Aldrich

Monoclonal Anti-Oncostatin M antibody produced in mouse

clone 17001, purified immunoglobulin, lyophilized powder

Synonym(s):
Anti-OSM
EC Number:
MDL number:
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

17001, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

indirect ELISA: suitable
neutralization: suitable
western blot: suitable

isotype

IgG2a

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... OSM(5008)

General description

Oncostatin M (OSM) is a growth-regulating cytokine produced by the activated T lymphocytes and macrophages. It has a pivotal role in stimulating the production of IL-6 in cultured human endothelial cells[1]. It also facilitates the LDL receptor expression and its uptake by hepatoma cells[2]. Further, OSM can induce synovial fibroblast-like cells to produce urokinase type plasminogen activator[3]. Monoclonal anti-Oncostatin M antibody can be used for neutralizing the biological activity of rhOSM on the human TF-1 cell line[4]. Mouse anti-Oncostatin M antibody reacts specifically with recombinant human OSM. The product has shown no cross-reactivity with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Specificity

The antibody neutralizes the biological activity of recombinant human OSM. Does not cross-react with recombinant human IL-6, IL-11, CNTF, LIF and recombinant mouse OSM.

Immunogen

recombinant human OSM expressed in Escherichia coli.

Application

Monoclonal anti-Oncostatin M antibody can be used in western blotting and capture ELISA.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (PBS) with 5% trehalose.

Preparation Note

Purified using protein A.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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