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Merck

O9504

Oxaloacetic acid

powder, suitable for hybridoma

Synonym(s):

2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid

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About This Item

Linear Formula:
HOOCCH2COCOOH
CAS Number:
328-42-7
Molecular Weight:
132.07
UNSPSC Code:
12352205
NACRES:
NA.75
PubChem Substance ID:
24898071
EC Number:
206-329-8
Beilstein/REAXYS Number:
1705475
MDL number:
MFCD00002592

Key Documents

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Product Name

Oxaloacetic acid, powder, suitable for hybridoma

InChI key

KHPXUQMNIQBQEV-UHFFFAOYSA-N

InChI

1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)

SMILES string

OC(=O)CC(=O)C(O)=O

assay

≥97% (HPLC)

form

powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

solubility

H2O: 100 mg/mL

storage temp.

−20°C

Quality Level

200

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Application

Use as a TCA (Krebs cycle) intermediate supplement in hybridoma cell culture applications. Enhances hybridoma growth and productivity.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000501417
0000501417
0000366662
0000308464
0000308464

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Francisco Campos et al.
The international journal of biochemistry & cell biology, 44(2), 262-265 (2011-11-17)
It is well established that glutamate acts as an important mediator of neuronal degeneration during cerebral ischemia. Different kind of glutamate antagonists have been used to reduce the deleterious effects of glutamate. However, their preclinical success failed to translate into
Eva Brekke et al.
Glia, 60(1), 147-158 (2011-11-05)
Pyruvate carboxylation (PC) is thought to be the major anaplerotic reaction for the tricarboxylic acid cycle and is necessary for de novo synthesis of amino acid neurotransmitters. In the brain, the main enzyme involved is pyruvate carboxylase, which is predominantly
E Esenmo et al.
The American journal of physiology, 263(1 Pt 1), E36-E41 (1992-07-01)
Estimating the rate of hepatic gluconeogenesis in vivo from the incorporation of 14C from 14CO2 into glucose requires determination of the rates in liver of equilibration of oxaloacetate with fumarate, conversion of oxaloacetate to phosphoenolpyruvate (PEP), and conversion of PEP
E Dworzak et al.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 23(6), 323-329 (1985-06-01)
Evidence is presented for defective pyruvate dehydrogenase (EC 4.1.1.1) in leukocytes and muscle tissue from a 10-year old child with persistent lactic acidosis, suffering from myasthenia and growth retardation. The defect is expressed in vitro by a depressed stimulation of
Anthony Gandin et al.
Plant & cell physiology, 53(9), 1627-1637 (2012-08-01)
In higher plants, the mitochondrial electron transport chain has non-phosphorylating alternative pathways that include the alternative terminal oxidase (AOX). This alternative pathway has been suggested to act as a sink for dissipating excess reducing power, minimizing oxidative stress and possibly
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