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O0886

Olomoucine

≥98% (HPLC)

Sinonimo/i:

2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

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Cambia visualizzazione
Taglio della confezioneSKUDisponibilitàPrezzo
1 mg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
€86.90
€73.86
5 mg
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
€243.00
€206.55

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C15H18N6O
Numero CAS:
101622-51-9
Peso molecolare:
298.34
NACRES:
NA.77
PubChem Substance ID:
24278053
UNSPSC Code:
12352200
MDL number:
MFCD00189360
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

€73.86

Prezzo di listino€86.90Risparmia il 15%
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
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Quality Level

100

assay

≥98% (HPLC)

form

powder

solubility

DMSO: 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12

InChI

1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)

InChI key

GTVPOLSIJWJJNY-UHFFFAOYSA-N

Gene Information

human ... CDC2(983), CDK2(1017), CDK3(1018), CDK4(1019), CDK5(1020), CDK6(1021), CDK7(1022), CDK8(1024), CDK9(1025), CDKN1A(1026), CDKN1B(1027), CDKN1C(1028), CDKN2A(1029), CDKN2B(1030), CDKN2C(1031), CDKN2D(1032), CDKN3(1033)
rat ... Prkca(24680)

Biochem/physiol Actions

Olomoucine is a purine derivative which inhibits cyclin-dependent kinases and induces G arrest.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Olomoucine ≥98% (HPLC)

Sigma-Aldrich

O0886

Olomoucine

Ogerin ≥98% (HPLC)

Sigma-Aldrich

SML1482

Ogerin

Purmorphamine ≥98% (HPLC)

Sigma-Aldrich

SML0868

Purmorphamine

SMBA1 ≥98% (HPLC)

Sigma-Aldrich

SML1464

SMBA1

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 20 mg/mL, clear, colorless

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 20 mg/mL, clear

Gene Information

human ... CDC2(983), CDK2(1017), CDK3(1018), CDK4(1019), CDK5(1020), CDK6(1021), CDK7(1022), CDK8(1024), CDK9(1025), CDKN1A(1026), CDKN1B(1027), CDKN1C(1028), CDKN2A(1029), CDKN2B(1030), CDKN2C(1031), CDKN2D(1032), CDKN3(1033)
rat ... Prkca(24680)

Gene Information

-

Gene Information

-

Gene Information

-

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Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
MKCV0158
MKCR9067
MKCR1870
MKCS3267
MKBW6142V

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R T Abraham et al.
Biology of the cell, 83(2-3), 105-120 (1995-01-01)
Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. The unusual specificity of this compound towards cell
J Veselý et al.
European journal of biochemistry, 224(2), 771-786 (1994-09-01)
While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2-hydroxyethylamino)-6- benzylamino-9-methylpurine (olomoucine). Kinetic analysis of kinase inhibition reveals that olomoucine
Wei Mao et al.
Journal of experimental & clinical cancer research : CR, 31, 49-49 (2012-05-25)
Gastrokine-1 (GKN1), a secreted protein, is specifically expressed in gastric mucosa to protect and maintain the integrity of gastric epithelium. The present study investigated differential expression of GKN1 in normal, precancerous, and cancerous gastric tissues, and explored the biological functions
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Numero articolo commerciale globale

SKUGTIN
O0886-5MG04061834212676
O0886-1MG04061834212669

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