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Cationic PEGylated Liposomes

Name: Cationic PEGylated Liposomes
Brand: ALDRICH

DSPC:Chol:DSTAP:DSPE-PEG(2000) (55:30:10:5 molar ratio 10mM)

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About This Item

NACRES:

NA.25

UNSPSC Code:

12352211

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Properties

composition

Phosphate buffered saline

concentration

10 mM

impurities

10 mol % DSTAP, 30 mol % Cholesterol , 5 mol % DSPE-PEG2000, 55 mol % DSPC

particle size

100 nm

pH

7.4

Description

General description

Poly(ethylene glycol) (PEG) is commonly added to liposomes to improve stability, hydrophilicity and enhance circulation time. Anionic PEGylated liposomes protect liposomes from circulating proteins, improving their plasma clearance and enhancing their therapeutic effects. In addition, anionic liposomes demonstrate greater stability in solution, lead to lower aggregation when compared to neutral liposomes, and have increased endocytosis when compared with cationic and neutral liposomes.

Application

Drug delivery
Lipid-protein interactions

Preparation Note

Liposomes should never be frozen. Liposomes should be stored in the dark at 4°C, except when brought to room temperature for brief periods prior to use.

Liposomes are made under sterile conditions. If you need to take multiple aliquots out of the vial, it is advised to take extreme care in not contaminating the vial. It is recommended to handle the vial under a sterile hood to maintain the sterility of the product. Liposomes should never be frozen. Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size of liposomes particles.

Legal Information

Cellsome is a trademark of Encapsula NanoSciences

Product of Encapsula Nanosciences

Disclaimer

For research use only

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This Item	CPGG501	CPSG501	CPSG502
Sigma-Aldrich CDPG501 Cationic PEGylated Liposomes	Sigma-Aldrich CPGG501 Anionic PEGylated Liposomes	Sigma-Aldrich CPSG501 Anionic PEGylated Liposomes	Sigma-Aldrich CPSG502 Anionic PEGylated Liposomes
description DSPC:Chol:DSTAP:DSPE-PEG(2000) (55:30:10:5 molar ratio 10mM)	description DSPC:Chol:DSPG:DSPE-PEG(2000) (60:30:5:5 molar ratio 10mM)	description DSPC:Chol:DSPS:DSPE-PEG(2000) (60:30:5:5 molar ratio 10mM)	description DOPC:Chol:DOPS:DOPE-PEG(2000) (60:30:5:5 molar ratio 10mM)
concentration 10 mM	concentration 10 mM	concentration 10 mM	concentration 10 mM
composition Phosphate buffered saline	composition Phosphate buffered saline	composition Phosphate buffered saline	composition Phosphate buffered saline
impurities 10 mol % DSTAP, 30 mol % Cholesterol , 55 mol % DSPC, 5 mol % DSPE-PEG2000	impurities 30 mol % Cholesterol , 60 mol % DSPC, 5 mol % DSPG, 5 mol % DSPE-PEG2000	impurities 5 mol % DSPS, 30 mol % Cholesterol , 60 mol % DSPC, 5 mol % DSPE-PEG2000	impurities 5 mol % DOPS, 30 mol % Cholesterol , 60 mol % DOPC, 5 mol % DOPE-PEG2000
particle size 100 nm	particle size 100 nm	particle size 100 nm	particle size 100 nm
pH 7.4	pH 7.4	pH 7.4	pH 7.4

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Storage Class

12 - Non Combustible Liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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