407331

Cpd 22

≥94% (HPLC), integrin-linked kinase inhibitor, powder

• Synonym(s): ILK inhibitor, Cpd 22
• Empirical Formula (Hill Notation): C₃₀H₃₀F₃N₅O
• Molecular Weight: 533.59
• UNSPSC Code: 12352200
• NACRES: NA.77
• eCl@ss: 32160702
• Assay: ≥94% (HPLC)
• Form: powder
• Storage condition: OK to freeze, protect from light

Properties

• Product Name: ILK inhibitor, Cpd 22, The ILK inhibitor, Cpd 22 controls the biological activity of ILK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
• Quality Segment: 100
• assay: ≥94% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: off-white
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

A cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC₅₀ = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC₅₀ = 1 to 2.5 µM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lee, S., et al. 2011. J. Med. Chem.54, 6364

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable