5.04635

MPEP Hydrochloride

• Synonym(s): MPEP Hydrochloride, 6-Methyl-2-(phenylethynyl)pyridine hydrochloride
• CAS Number: 96206-92-7
• UNSPSC Code: 12352200
• Assay: ≥99% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Properties

• assay: ≥99% (HPLC)
• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: DMSO: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
• InChI key: NEWKHUASLBMWRE-UHFFFAOYSA-N

Description

General description

A non-competitive, highly potent antagonist selective for mGlu₅ receptors (IC₅₀ = 36 nM). Also a positive allosteric modulator of mGlu₄and weak anatagonist of NMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu₅ receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson′s disease.

Biochem/physiol Actions

Primary Target
mGlu₅ receptors

Preparation Note

Following reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Manago, F., et al. 2013. Psychopharmacol. (Berl)226, 541.
Cavas, M., et al. 2013. Prog. Neuropsychopharmacol. Biol. Psychiatry.40, 18.
Micheli, F., 2000. Cur. Op. Invest. Drugs (London, England)1, 355.
Li, X., et al. 2006. J. Pharmacol. & Exp. Therapeutics.319, 254.
Tatarczyñska, E., et al. 2001. Bri. J. Pharmacol.132, 1423.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable