8.52007
Fmoc-Cys(tBu)-OH
Novabiochem®
Synonym(s):
Fmoc-Cys(tBu)-OH, N-α-Fmoc-S-t.-butyl-L-cysteine
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| Size/SKU | Availability | Price |
|---|---|---|
25 g | Please contact Customer Service for Availability | 8 540,00 CZK |
100 g | Please contact Customer Service for Availability | 25 500,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C22H25NO4S
CAS Number:
Molecular Weight:
399.50
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
Quality Segment
product line
Novabiochem®
assay
≥97.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
mp
133-136 °C
application(s)
peptide synthesis
functional group
thiol
storage temp.
2-30°C
SMILES string
S(C(C)(C)C)CC(NC(=O)OCC1c2c(cccc2)c3c1cccc3)C(=O)O
InChI
1S/C22H25NO4S/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)
InChI key
IXAYZHCPEYTWHW-UHFFFAOYSA-N
General description
The side-chain tBu group is stable to TFA and iodine oxidation. Treatment with MeSiCl3/PhSOPh removes t-Bu and cyclizes in one step without scrambling existing disulphide bonds. Removed with Hg(II) to give cysteinyl peptides.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides
Literature references
[1] S. N. McCurdy (1989) Pept. Res., 2, 147.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides
Literature references
[1] S. N. McCurdy (1989) Pept. Res., 2, 147.
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Other Notes
Replaces: 04-12-1016
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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