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MATHKSA

HKSA Non-Endotoxin Pyrogen (NEP) Control

for use with PyroMAT® System

Synonym(s):

NEP, NEP control

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Size/SKUAvailabilityPrice
1 vial

Available to ship TODAYfromAreál Kühne+Nagel spol. s r.o.

14 300,00 CZK

About This Item

NACRES:
NA.24
UNSPSC Code:
41116130
Suitability:
pyrogenic bacteria
Manufacturer/tradename:
PyroMAT®
Application(s):
pharmaceutical
pyrogen testing
Storage temp.:
2-8°C

14 300,00 CZK

Available to ship TODAYDetails

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Quality Segment

400

product line

PyroMAT®

packaging

pkg of 1 vial

manufacturer/tradename

PyroMAT®

application(s)

pharmaceutical
pyrogen testing

compatibility

for use with PyroMAT® System

shipped in

ambient

storage temp.

2-8°C

suitability

pyrogenic bacteria

General description

The PyroMAT® System uses cryopreserved Mono-Mac-6 (MM6) human monocytic cells as a source of monocytes. The response to a full range of pyrogens, including endotoxins and non-endotoxin pyrogens (NEPs) is determined by the measurement of interleukin-6 (IL-6) produced by the Mono-Mac-6 cells using ELISA. NEP control HKSA is a heat-killed preparation of Staphylococcus aureus, supplied in a lyophilized form. It is designed to mimic the NEP of Gram positive bacteria origin.

HKSA is a non-endotoxin pyrogen (NEP) that activates the TLR2 receptor of monocytes and can be used as a positive control with the PyroMAT® System (Monocyte Activation Test for pyrogen detection).

Application

NEP control of heat-killed Staphylococcus aureus can be used as a positive control with the PyroMAT® System. It is to be used for Product Specific Validation (PSV) and routine testing to show that the system can detect non-endotoxin pyrogen contaminants in pharmaceutical products.

Biochem/physiol Actions

TLR-2 agonist

Features and Benefits

Endotoxin-free product at concentration of use in MAT

Preparation Note

Store unopened vials at 2-8°C

Do not use unopened vials after expiration date

Store resuspended aliquots at -20°C

Legal Information

PYROMAT is a registered trademark of Merck KGaA, Darmstadt, Germany

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PAM3CSK4 Non-Endotoxin Pyrogen (NEP) Control for use with PyroMAT®

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MATPAM3CSK4

PAM3CSK4 Non-Endotoxin Pyrogen (NEP) Control

description

for use with PyroMAT® System

description

for use with PyroMAT® System

description

kit containing all reagents to perform the Monocyte Activation Test (MAT) for Pyrogen testing, including the IL-6 Standard (control) and IL-6 ELISA kit, suitable for pyrogen testing

description

for use with PyroMAT®

suitability

pyrogenic bacteria

suitability

pyrogenic bacteria

suitability

-

suitability

pyrogenic bacteria

manufacturer/tradename

PyroMAT®

manufacturer/tradename

PyroMAT®

manufacturer/tradename

PyroMAT®

manufacturer/tradename

PyroMAT®

compatibility

configured for PyroDetect System, configured for PyroMAT® System

compatibility

configured for PyroDetect System, configured for PyroMAT® System

compatibility

configured for PyroMAT®

compatibility

for use with PyroMAT®

Quality Level

400

Quality Level

400

Quality Level

400

Quality Level

400

application(s)

pharmaceutical
pyrogen testing

application(s)

pharmaceutical
pyrogen testing

application(s)

pharmaceutical, pyrogen testing

application(s)

pharmaceutical
pyrogen testing

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

pictograms

Exclamation mark
GHS07

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

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