PMB3003

L-Arginine monohydrochloride

98.5-101%, ISOM8^™, suitable for cell culture, from non-animal source

• Synonym(s): L-Arginine monohydrochloride, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride, (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride
• Empirical Formula (Hill Notation): C₆H₁₄N₄O₂ · HCl
• CAS Number: 1119-34-2
• Molecular Weight: 210.66
• UNSPSC Code: 12352200
• Beilstein/REAXYS Number: 3631658
• MDL number: MFCD00064550

Properties

• biological source: non-animal source
• Quality Segment: 400
• agency: meets EP, meets JP, meets USP, meets requirements for USP (testing)
• product line: ISOM8^™
• assay: 98.5-101%
• form: crystalline powder
• optical activity: [α]/D 22.1-22.9°, c = 6 M in HCl (8 in 6 M HCl)
• technique(s): cell culture | mammalian: suitable
• color: white
• mp: 226-230 °C
• functional group: (Guanidine), amine, carboxylic acid
• storage temp.: room temp
• SMILES string: Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
• InChI key: KWTQSFXGGICVPE-WCCKRBBISA-N

Description

General description

L-Arginine Monohydrochloride is the hydrochloride salt of L-Arginine, an essential, basic amino acid. As a cationic amino acid, L-Arginine contains a guanidino group in its side chain, which gives it a strong positive charge at physiological pH and contributes to its roles in various biochemical and cellular processes. The hydrochloride form enhances the compound′s solubility and stability, making it suitable for a wide range of aqueous applications.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Features and Benefits

Features:

1. Qualified Raw Materials: Products that meet the stringent requirements of the Elevated Assurance Program, ensuring compliance with regulatory standards.
2. Comprehensive Documentation: Includes essential documents such as certificates, impurity profiles, and declarations to support audits and risk assessments.
3. M-Clarity^™ Quality Attributes: Products are classified within the MQ300 quality segment or higher, demonstrating superior quality assurance. https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/m-clarity-program
4. Confirmed Process Controls: Established processes that ensure consistency and reliability in manufacturing.
5. Enhanced Change Notification: Timely updates on any changes to product specifications or processes, ensuring transparency and compliance.
6. Freely Available Dossiers: Access to robust, ready-to-present product dossiers that include:

• Site quality assessment
• ISO 9001 certificate
• Detailed product specifications
• Relevant declarations/statements (e.g., animal origin content, BSE/TSE, nitrosamine)

Benefits:

1. Regulatory Compliance: Helps you meet compliance standards effectively, reducing the risk of regulatory issues.
2. Audit Readiness: Instills confidence during audits with comprehensive documentation and confirmed process controls, demonstrating your commitment to high-quality products.
3. Operational Transparency: Supports supply chain transparency, allowing you to track and verify the quality of raw materials.
4. Enhanced Support: Provides exceptional quality-related information and tailored assistance to meet your specific needs.
5. Risk Mitigation: Facilitates thorough risk assessments with detailed documentation, helping you manage potential compliance challenges.
6. Informed Decision-Making: Access to clear and comprehensive product information enables better decision-making and enhances operational efficiency.

Legal Information

ISOM8 is a trademark of Sigma-Aldrich Co. LLC

M-CLARITY is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable