A1355

Anti-Archvillin antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, PBS solution

• Synonym(s): Anti-SVIL, Anti-Supervillin (p205/p250), Anti-Supervillin isoform 2, SmAV (Smooth muscle Archvillin)
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD07784599
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IF, IHC (p), WB
• Citations: 3

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: PBS solution
• mol wt: antigen ~250 kDa
• species reactivity: rat, mouse, human
• concentration: ~1 mg/mL
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 20-40 μg/mL using heat-retrieved tissue sections from human heart by biotin/ExtrAvidin-Peroxidase, indirect immunofluorescence: 20-40 μg/mL using differentiated rat L8 cells, western blot: 2.5-5 μg/mL using whole extract of differentiated mouse C2 cells
• UniProt accession no.: O95425
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SVIL(6840) ; mouse ... Svil(225115) ; rat ... Svil(361256)

Description

General description

Archvillin is a muscle-specific isoform of Supervillin. Archvillin binds F-actin and is believed to be involved in myogenesis and muscle cell migration. Archvillin binds ERK and modulates ERK signaling in smooth cells of the aortas of ferrets.

Rabbit anti-archvillin antibody binds to human, mouse, and rat archvillin.

Immunogen

synthetic peptide corresponding to amino acid residues 650-666 of human archvillin. The corresponding sequence is identical in mouse.

Application

Rabbit anti-archvillin antibody can be used for immunohistochemistry at 20-40 μg/mL using heat-retrieved tissue sections from human heart by biotin/ExtrAvidin-Peroxidase. The antibody can also be used for indirect immunofluorescence at 20-40 μg/mL using differentiated rat L8 cells. Furthermore, the antibody is suitable for use in western blot (2.5-5 μg/mL using whole extract of differentiated mouse C2 cells) assays.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable