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A3111

A1120

≥98% (HPLC), powder

Synonym(s):

2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
2 640,00 CZK
25 mg
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12 300,00 CZK

About This Item

Empirical Formula (Hill Notation):
C20H19F3N2O3
CAS Number:
1152782-19-8
Molecular Weight:
392.37
NACRES:
NA.77
PubChem Substance ID:
329770816
UNSPSC Code:
12352200
MDL number:
MFCD12912393
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

2 640,00 CZK

Please contact Customer Service for Availability
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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

off-white

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)c1ccccc1NC(=O)N2CCC(CC2)c3ccccc3C(F)(F)F

InChI

1S/C20H19F3N2O3/c21-20(22,23)16-7-3-1-5-14(16)13-9-11-25(12-10-13)19(28)24-17-8-4-2-6-15(17)18(26)27/h1-8,13H,9-12H2,(H,24,28)(H,26,27)

InChI key

MEAQCLPMSVEOQF-UHFFFAOYSA-N

Biochem/physiol Actions

A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4).
A1120 is a selective non-retinoid ligand for retinol-binding protein 4 (RBP4). RBP4 transports retinol from the liver to extrahepatic tissues and RBP4 lowering is reported to improve insulin sensitivity in mice. A1120 is a high affinity non-retinoid ligand for RBP4 which disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). It binds to the same site as retinol and induces changes in the orientation (compared to the retinol bound form) of loops at the RBP4-TTR interaction interface.A1120 lowers RBP4 and retinol levels in a dose-dependent manner, to a similar extent as seen with fenretinide. However, unlike fenretinide (Sigma# H7779), A1120 does not have beneficial effects on insulin resistance.

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A1120 ≥98% (HPLC), powder

Sigma-Aldrich

A3111

A1120

Canine RBP4 ELISA for serum, plasma and cell culture supernatants

Sigma-Aldrich

RAB1208

Canine RBP4 ELISA

Methyl 2-isocyanatobenzoate 97%

Sigma-Aldrich

439983

Methyl 2-isocyanatobenzoate

Mouse RBP4 ELISA for serum, plasma and cell culture supernatants

Sigma-Aldrich

RAB1860

Mouse RBP4 ELISA

description

≥98% (HPLC), powder

description

for serum, plasma and cell culture supernatants

description

97%

description

for serum, plasma and cell culture supernatants

assay

≥98% (HPLC)

assay

-

assay

97%

assay

-

form

powder

form

-

form

solid

form

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: ≥10 mg/mL

solubility

-

solubility

-

solubility

-

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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